Rare Hematologic Malignancies and Pre-Leukemic Entities in Children and Adolescents Young Adults

There are a variety of rare hematologic malignancies and germline predispositions syndromes that occur in children and adolescent young adults (AYAs). These entities are important to recognize, as an accurate diagnosis is essential for risk assessment, prognostication, and treatment. This descriptiv...

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Bibliographic Details
Published in:Cancers 2024-02, Vol.16 (5), p.997
Main Authors: Brown, Amber, Batra, Sandeep
Format: Article
Language:English
Subjects:
Anemia
Bone marrow
Chemotherapy
Children
Development and progression
Diagnosis
Disease
Females
Hemoglobin
Leukemia
Malignancy
Medical prognosis
Mutation
Neutrophils
Pathogenesis
Radiation therapy
Review
Risk assessment
Standard of care
Tumors
Young adults
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Summary:There are a variety of rare hematologic malignancies and germline predispositions syndromes that occur in children and adolescent young adults (AYAs). These entities are important to recognize, as an accurate diagnosis is essential for risk assessment, prognostication, and treatment. This descriptive review summarizes rare hematologic malignancies, myelodysplastic neoplasms, and germline predispositions syndromes that occur in children and AYAs. We discuss the unique biology, characteristic genomic aberrations, rare presentations, diagnostic challenges, novel treatments, and outcomes associated with these rare entities.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers16050997