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Current Status and Future Directions of Image-Guided Adaptive Brachytherapy for Locally Advanced Cervical Cancer
The standard of care for patients with locally advanced cervical cancer is definitive chemoradiation followed by a brachytherapy boost. This review describes the current status and future directions of image-guided adaptive brachytherapy for locally advanced cervical cancer. A systematic search of t...
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| Published in: | Cancers 2024-03, Vol.16 (5), p.1031 |
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| creator | Eustace, Nicholas Liu, Jason Ladbury, Colton Tam, Andrew Glaser, Scott Liu, An Chen, Yi-Jen |
| description | The standard of care for patients with locally advanced cervical cancer is definitive chemoradiation followed by a brachytherapy boost. This review describes the current status and future directions of image-guided adaptive brachytherapy for locally advanced cervical cancer.
A systematic search of the PubMed and Clinicaltrials.gov databases was performed, focusing on studies published within the last 10 years. The search queried "cervical cancer [AND] image-guided brachytherapy [OR] magnetic resonance imaging (MRI) [OR] adaptive brachytherapy".
The retroEMBRACE and EMBRACE-I trials have established the use of MRI as the standard imaging modality for brachytherapy application and planning. Quantitative imaging and radiomics have the potential to improve outcomes, with three ongoing prospective studies examining the use of radiomics to further risk-stratify patients and personalize brachytherapy. Another active area of investigation includes utilizing the superior soft tissue contrast provided by MRI to increase the dose per fraction and decrease the number of fractions needed for brachytherapy, with several retrospective studies demonstrating the safety and feasibility of three-fraction courses. For developing countries with limited access to MRI, trans-rectal ultrasound (TRUS) appears to be an effective alternative, with several retrospective studies demonstrating improved target delineation with the use of TRUS in conjunction with CT guidance.
Further investigation is needed to continue improving outcomes for patients with locally advanced cervical cancer treated with image-guided brachytherapy. |
| doi_str_mv | 10.3390/cancers16051031 |
| format | article |
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A systematic search of the PubMed and Clinicaltrials.gov databases was performed, focusing on studies published within the last 10 years. The search queried "cervical cancer [AND] image-guided brachytherapy [OR] magnetic resonance imaging (MRI) [OR] adaptive brachytherapy".
The retroEMBRACE and EMBRACE-I trials have established the use of MRI as the standard imaging modality for brachytherapy application and planning. Quantitative imaging and radiomics have the potential to improve outcomes, with three ongoing prospective studies examining the use of radiomics to further risk-stratify patients and personalize brachytherapy. Another active area of investigation includes utilizing the superior soft tissue contrast provided by MRI to increase the dose per fraction and decrease the number of fractions needed for brachytherapy, with several retrospective studies demonstrating the safety and feasibility of three-fraction courses. For developing countries with limited access to MRI, trans-rectal ultrasound (TRUS) appears to be an effective alternative, with several retrospective studies demonstrating improved target delineation with the use of TRUS in conjunction with CT guidance.
Further investigation is needed to continue improving outcomes for patients with locally advanced cervical cancer treated with image-guided brachytherapy.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers16051031</identifier><identifier>PMID: 38473388</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Brachytherapy ; Cancer ; Cancer therapies ; Care and treatment ; Cervical cancer ; Cervix ; Chemoradiotherapy ; Clinical trials ; Developing countries ; Dosimetry ; Drug dosages ; Human papillomavirus ; Immunization ; LDCs ; Lymphatic system ; Magnetic resonance imaging ; Medical imaging equipment ; Metastasis ; Oncology, Experimental ; Radiation therapy ; Radioisotope brachytherapy ; Radiomics ; Review ; Standard of care ; Toxicity ; Ultrasonic imaging ; Vagina</subject><ispartof>Cancers, 2024-03, Vol.16 (5), p.1031</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-5aa2c3380eb069b8df6d6752adc9589feadd44e9a406f88b73c9f32b1191b58e3</citedby><cites>FETCH-LOGICAL-c489t-5aa2c3380eb069b8df6d6752adc9589feadd44e9a406f88b73c9f32b1191b58e3</cites><orcidid>0000-0003-2287-2320 ; 0000-0002-2668-3415</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2955430795/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2955430795?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38473388$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eustace, Nicholas</creatorcontrib><creatorcontrib>Liu, Jason</creatorcontrib><creatorcontrib>Ladbury, Colton</creatorcontrib><creatorcontrib>Tam, Andrew</creatorcontrib><creatorcontrib>Glaser, Scott</creatorcontrib><creatorcontrib>Liu, An</creatorcontrib><creatorcontrib>Chen, Yi-Jen</creatorcontrib><title>Current Status and Future Directions of Image-Guided Adaptive Brachytherapy for Locally Advanced Cervical Cancer</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>The standard of care for patients with locally advanced cervical cancer is definitive chemoradiation followed by a brachytherapy boost. This review describes the current status and future directions of image-guided adaptive brachytherapy for locally advanced cervical cancer.
A systematic search of the PubMed and Clinicaltrials.gov databases was performed, focusing on studies published within the last 10 years. The search queried "cervical cancer [AND] image-guided brachytherapy [OR] magnetic resonance imaging (MRI) [OR] adaptive brachytherapy".
The retroEMBRACE and EMBRACE-I trials have established the use of MRI as the standard imaging modality for brachytherapy application and planning. Quantitative imaging and radiomics have the potential to improve outcomes, with three ongoing prospective studies examining the use of radiomics to further risk-stratify patients and personalize brachytherapy. Another active area of investigation includes utilizing the superior soft tissue contrast provided by MRI to increase the dose per fraction and decrease the number of fractions needed for brachytherapy, with several retrospective studies demonstrating the safety and feasibility of three-fraction courses. For developing countries with limited access to MRI, trans-rectal ultrasound (TRUS) appears to be an effective alternative, with several retrospective studies demonstrating improved target delineation with the use of TRUS in conjunction with CT guidance.
Further investigation is needed to continue improving outcomes for patients with locally advanced cervical cancer treated with image-guided brachytherapy.</description><subject>Brachytherapy</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Cervical cancer</subject><subject>Cervix</subject><subject>Chemoradiotherapy</subject><subject>Clinical trials</subject><subject>Developing countries</subject><subject>Dosimetry</subject><subject>Drug dosages</subject><subject>Human papillomavirus</subject><subject>Immunization</subject><subject>LDCs</subject><subject>Lymphatic system</subject><subject>Magnetic resonance imaging</subject><subject>Medical imaging equipment</subject><subject>Metastasis</subject><subject>Oncology, Experimental</subject><subject>Radiation therapy</subject><subject>Radioisotope brachytherapy</subject><subject>Radiomics</subject><subject>Review</subject><subject>Standard of care</subject><subject>Toxicity</subject><subject>Ultrasonic imaging</subject><subject>Vagina</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNptkkFv3CAQha2qVRKlOedWIfXSixMwGMOp2rpJGmmlHtqeEYZhl8g2Ltgr7b8vm6RpEhUOjIbvPWbQFMU5wReUSnxp9GggJsJxTTAlb4qTCjdVyblkb5_Fx8VZSnc4L0pJw5uj4pgK1lAqxEkxtUuMMM7ox6znJSE9WnS9zEsE9NVHMLMPY0LBodtBb6C8WbwFi1ZWT7PfAfoStdnu5y1EPe2RCxGtg9F9v8_I7lCeRS3Enc851N6X-75453Sf4OzxPC1-XV_9bL-V6-83t-1qXRom5FzWWlcml4ihw1x2wjpueVNX2hpZC-lAW8sYSM0wd0J0DTXS0aojRJKuFkBPi88PvtPSDWBN7jHqXk3RDzruVdBevbwZ_VZtwk4RLCnBNc8Onx4dYvi9QJrV4JOBvtcjhCWpStacC8a4zOjHV-hdWOKY-ztQNaO4kfU_aqN7UH50IT9sDqZq1QjOMsqqTF38h8rbwuBNGMH5nH8huHwQmBhSiuCemiRYHQZFvRqUrPjw_G-e-L9jQf8A0Dm6aQ</recordid><startdate>20240302</startdate><enddate>20240302</enddate><creator>Eustace, Nicholas</creator><creator>Liu, Jason</creator><creator>Ladbury, Colton</creator><creator>Tam, Andrew</creator><creator>Glaser, Scott</creator><creator>Liu, An</creator><creator>Chen, Yi-Jen</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2287-2320</orcidid><orcidid>https://orcid.org/0000-0002-2668-3415</orcidid></search><sort><creationdate>20240302</creationdate><title>Current Status and Future Directions of Image-Guided Adaptive Brachytherapy for Locally Advanced Cervical Cancer</title><author>Eustace, Nicholas ; Liu, Jason ; Ladbury, Colton ; Tam, Andrew ; Glaser, Scott ; Liu, An ; Chen, Yi-Jen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-5aa2c3380eb069b8df6d6752adc9589feadd44e9a406f88b73c9f32b1191b58e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Brachytherapy</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Cervical cancer</topic><topic>Cervix</topic><topic>Chemoradiotherapy</topic><topic>Clinical trials</topic><topic>Developing countries</topic><topic>Dosimetry</topic><topic>Drug dosages</topic><topic>Human papillomavirus</topic><topic>Immunization</topic><topic>LDCs</topic><topic>Lymphatic system</topic><topic>Magnetic resonance imaging</topic><topic>Medical imaging equipment</topic><topic>Metastasis</topic><topic>Oncology, Experimental</topic><topic>Radiation therapy</topic><topic>Radioisotope brachytherapy</topic><topic>Radiomics</topic><topic>Review</topic><topic>Standard of care</topic><topic>Toxicity</topic><topic>Ultrasonic imaging</topic><topic>Vagina</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eustace, Nicholas</creatorcontrib><creatorcontrib>Liu, Jason</creatorcontrib><creatorcontrib>Ladbury, Colton</creatorcontrib><creatorcontrib>Tam, Andrew</creatorcontrib><creatorcontrib>Glaser, Scott</creatorcontrib><creatorcontrib>Liu, An</creatorcontrib><creatorcontrib>Chen, Yi-Jen</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Biological Science Collection</collection><collection>ProQuest research library</collection><collection>ProQuest Biological Science Journals</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eustace, Nicholas</au><au>Liu, Jason</au><au>Ladbury, Colton</au><au>Tam, Andrew</au><au>Glaser, Scott</au><au>Liu, An</au><au>Chen, Yi-Jen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Current Status and Future Directions of Image-Guided Adaptive Brachytherapy for Locally Advanced Cervical Cancer</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2024-03-02</date><risdate>2024</risdate><volume>16</volume><issue>5</issue><spage>1031</spage><pages>1031-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>The standard of care for patients with locally advanced cervical cancer is definitive chemoradiation followed by a brachytherapy boost. This review describes the current status and future directions of image-guided adaptive brachytherapy for locally advanced cervical cancer.
A systematic search of the PubMed and Clinicaltrials.gov databases was performed, focusing on studies published within the last 10 years. The search queried "cervical cancer [AND] image-guided brachytherapy [OR] magnetic resonance imaging (MRI) [OR] adaptive brachytherapy".
The retroEMBRACE and EMBRACE-I trials have established the use of MRI as the standard imaging modality for brachytherapy application and planning. Quantitative imaging and radiomics have the potential to improve outcomes, with three ongoing prospective studies examining the use of radiomics to further risk-stratify patients and personalize brachytherapy. Another active area of investigation includes utilizing the superior soft tissue contrast provided by MRI to increase the dose per fraction and decrease the number of fractions needed for brachytherapy, with several retrospective studies demonstrating the safety and feasibility of three-fraction courses. For developing countries with limited access to MRI, trans-rectal ultrasound (TRUS) appears to be an effective alternative, with several retrospective studies demonstrating improved target delineation with the use of TRUS in conjunction with CT guidance.
Further investigation is needed to continue improving outcomes for patients with locally advanced cervical cancer treated with image-guided brachytherapy.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38473388</pmid><doi>10.3390/cancers16051031</doi><orcidid>https://orcid.org/0000-0003-2287-2320</orcidid><orcidid>https://orcid.org/0000-0002-2668-3415</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Brachytherapy Cancer Cancer therapies Care and treatment Cervical cancer Cervix Chemoradiotherapy Clinical trials Developing countries Dosimetry Drug dosages Human papillomavirus Immunization LDCs Lymphatic system Magnetic resonance imaging Medical imaging equipment Metastasis Oncology, Experimental Radiation therapy Radioisotope brachytherapy Radiomics Review Standard of care Toxicity Ultrasonic imaging Vagina |
| title | Current Status and Future Directions of Image-Guided Adaptive Brachytherapy for Locally Advanced Cervical Cancer |
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