Critical Roles of the Sphingolipid Metabolic Pathway in Liver Regeneration, Hepatocellular Carcinoma Progression and Therapy

The sphingolipid metabolic pathway, an important signaling pathway, plays a crucial role in various physiological processes including cell proliferation, survival, apoptosis, and immune regulation. The liver has the unique ability to regenerate using bioactive lipid mediators involving multiple sphi...

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Bibliographic Details
Published in:Cancers 2024-02, Vol.16 (5), p.850
Main Authors: Nojima, Hiroyuki, Shimizu, Hiroaki, Murakami, Takashi, Shuto, Kiyohiko, Koda, Keiji
Format: Article
Language:English
Subjects:
Angiogenesis
Antimitotic agents
Antineoplastic agents
Apoptosis
Cancer therapies
Cell growth
Cell proliferation
Cell survival
Ceramide
Cytokines
Development and progression
Enzymes
Fibrosis
FTY720
Health aspects
Hepatectomy
Hepatocellular carcinoma
Hepatoma
Immunoregulation
Kinases
Lipids
Liver
Liver cancer
Liver cirrhosis
Liver diseases
Metabolic pathways
Metabolism
Metabolites
Metastases
Phosphatase
Phosphates
Physiological aspects
Physiology
Review
Signal transduction
Sphingolipids
Sphingomyelin
Sphingosine
Sphingosine 1-phosphate
Stem cells
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Summary:The sphingolipid metabolic pathway, an important signaling pathway, plays a crucial role in various physiological processes including cell proliferation, survival, apoptosis, and immune regulation. The liver has the unique ability to regenerate using bioactive lipid mediators involving multiple sphingolipids, including ceramide and sphingosine 1-phosphate (S1P). Dysregulation of the balance between sphingomyelin, ceramide, and S1P has been implicated in the regulation of liver regeneration and diseases, including liver fibrosis and hepatocellular carcinoma (HCC). Understanding and modulating this balance may have therapeutic implications for tumor proliferation, progression, and metastasis in HCC. For cancer therapy, several inhibitors and activators of sphingolipid signaling, including ABC294640, SKI-II, and FTY720, have been discussed. Here, we elucidate the critical roles of the sphingolipid pathway in the regulation of liver regeneration, fibrosis, and HCC. Regulation of sphingolipids and their corresponding enzymes may considerably influence new insights into therapies for various liver disorders and diseases.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers16050850