Gingival Necrosis Related to Sepsis-Induced Agranulocytosis Due to Pseudomonas aeruginosa Bacteraemia: A Case Report

: There have been no reports of sepsis-induced agranulocytosis causing gingival necrosis in otherwise medically healthy patients to the authors' best knowledge. Even though there are several case reports of gingival necrosis secondary to medication-induced agranulocytosis, they have not systema...

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Bibliographic Details
Published in:Journal of clinical medicine 2024-02, Vol.13 (5), p.1285
Main Authors: Tan, Jia Ying, Teo, Guo Nian, Ng, Ethan, Tay, Andrew Ban Guan, Tay, John Rong Hao
Format: Article
Language:English
Subjects:
Abdomen
Blood
Bone marrow
Case Report
Developing countries
Emergency medical care
Granulocytes
Hematology
Hypotension
Immune system
LDCs
Leukocytes
Leukopenia
Neutropenia
Neutrophils
Nosocomial infections
Pain
Patients
Pneumonia
Sepsis
Teeth
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Summary:: There have been no reports of sepsis-induced agranulocytosis causing gingival necrosis in otherwise medically healthy patients to the authors' best knowledge. Even though there are several case reports of gingival necrosis secondary to medication-induced agranulocytosis, they have not systematically described the natural progression of agranulocytosis-related gingival necrosis. : This paper presents a case report of a 29-year-old female Indian patient with generalised gingival necrosis and constitutive signs of intermittent fever, nausea, and vomiting. She also complained of abdominal pains. Blood counts showed agranulocytosis, and the patient was admitted for a workup of the underlying cause. Parenteral broad-spectrum antibiotics were administered, which brought about clinical resolution. : Her gingival necrosis was attributed to sepsis-induced agranulocytosis triggered by bacteraemia, and upon clinical recovery, spontaneous exfoliation left behind exposed bone. Secondary healing over the exposed alveolar bone was noted after a year-long follow-up, albeit with some residual gingival recession. : Oral manifestations of gingival necrosis, when present with concomitant constitutive symptoms, could indicate a serious underlying systemic condition that could be potentially life-threatening if left untreated. Dentists should be cognizant of this possibility so that timely intervention is not delayed.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm13051285