Endothelial Migration and Regeneration after Penetrating Trauma Injury in a Deep Anterior Lamellar Keratoplasty Graft: Case Presentation and Literature Overview

: Traumatic injuries in eyes previously treated with Deep Anterior Lamellar Keratoplasty (DALK) can lead to ruptures in the Descemet Membrane (DM) and damage to the corneal endothelium, a crucial layer for maintaining corneal clarity. Due to cell cycle constraints, the human corneal endothelium cann...

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Bibliographic Details
Published in:Journal of clinical medicine 2024-02, Vol.13 (5), p.1424
Main Authors: Pagano, Luca, Borgia, Alfredo, Alfaqawi, Fadi, Makuloluwa, Aruni, Coco, Giulia, Giannaccare, Giuseppe, Messina, Marco, Romano, Vito, Gadhvi, Kunal
Format: Article
Language:English
Subjects:
Care and treatment
Case Report
Causes of
Cell adhesion & migration
Cell cycle
Cornea
Corneal transplantation
Dehiscence
Dissection
Edema
Endothelium
Eye
Eye surgery
Hydration
Injuries
Patients
Penetrating wounds
Steroids
Sutures
Transplantation
Trauma
Visual acuity
Wound dehiscence
Wound healing
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Summary:: Traumatic injuries in eyes previously treated with Deep Anterior Lamellar Keratoplasty (DALK) can lead to ruptures in the Descemet Membrane (DM) and damage to the corneal endothelium, a crucial layer for maintaining corneal clarity. Due to cell cycle constraints, the human corneal endothelium cannot proliferate; instead, it compensates for injury through cell enlargement and migration from adjacent areas. : This study examines a notable case of corneal endothelial cell migration following a penetrating eye injury in a patient previously treated with DALK for keratoconus, supplemented by a review of relevant literature to contextualize the regenerative response. : A 39-year-old male with a history of DALK suffered a traumatic eye injury, resulting in damage to the Descemet Membrane and loss of the crystalline lens. After primary repair and considerations for further surgery, the patient's cornea cleared remarkably, with an improved visual acuity. This demonstrates the DM's potential for self-repair through endothelial cell migration. : The outcomes suggest that delaying corneal transplant surgery for up to 3 months following Descemet Membrane injury due to ocular trauma could be advantageous. Allowing time for natural healing processes might eliminate the need for further invasive surgeries, thereby improving patient recovery outcomes.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm13051424