Therapeutic Approach in Pigmented Purpuric Dermatoses-A Scoping Review

Pigmented purpuric dermatoses (PPD) encompass a group of chronic skin conditions characterized by the presence of petechiae, purpura, and pigmentation changes. While generally benign, these dermatoses can be persistent and aesthetically bothersome. Key clinical features include red to brownish patch...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-02, Vol.25 (5), p.2644
Main Authors: Kimak, Agnieszka, Żebrowska, Agnieszka
Format: Article
Language:English
Subjects:
Antibiotics
Antigens
Biopsy
Blood
Blood vessels
Dendritic cells
Dermatitis
Development and progression
Diagnosis
Fungal infections
Health aspects
Hepatitis
Leukocytes
Nonsteroidal anti-inflammatory drugs
Pathogenesis
Pediatrics
Purpura
Review
Skin
Skin diseases
Steroids
Thrombocytopenia
Viral infections
Vitamin C
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Description
Summary:Pigmented purpuric dermatoses (PPD) encompass a group of chronic skin conditions characterized by the presence of petechiae, purpura, and pigmentation changes. While generally benign, these dermatoses can be persistent and aesthetically bothersome. Key clinical features include red to brownish patches with a distinctive "cayenne pepper" appearance, predominantly localized on the lower extremities, particularly the shins. Subtypes include Schamberg disease, Majocchi's disease, Gougerot-Blum disease, Ducas and Kapetanakis pigmented purpura, and lichen aureus. Diagnosis relies primarily on clinical evaluation of skin lesions, with biopsy as a confirmatory tool. Although the exact cause of PPD remains unclear, capillary fragility and red blood cell extravasation are implicated. Treatment strategies for PPD aim to alleviate symptoms, considering the generally benign and chronic nature of the condition. As there is no standardized treatment, various methods with varying efficacy are employed. After searching SCOPUS and PubMed databases, we assessed 42 original articles to present current knowledge regarding therapy of PPD. This review will compare treatment approaches specifically in Schamberg disease and other manifestations of pigmented purpuric dermatoses.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25052644