Therapeutic Approach in Pigmented Purpuric Dermatoses-A Scoping Review

• Published in: International journal of molecular sciences 2024-02, Vol.25 (5), p.2644
• Main Authors: Kimak, Agnieszka, Żebrowska, Agnieszka
• Format: Article
• Language: English
• Subjects: Antibiotics; Antigens; Biopsy; Blood; Blood vessels; Dendritic cells; Dermatitis; Development and progression; Diagnosis; Fungal infections; Health aspects; Hepatitis; Leukocytes; Nonsteroidal anti-inflammatory drugs; Pathogenesis; Pediatrics; Purpura; Review; Skin; Skin diseases; Steroids; Thrombocytopenia; Viral infections; Vitamin C
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25052644

Pigmented purpuric dermatoses (PPD) encompass a group of chronic skin conditions characterized by the presence of petechiae, purpura, and pigmentation changes. While generally benign, these dermatoses can be persistent and aesthetically bothersome. Key clinical features include red to brownish patches with a distinctive "cayenne pepper" appearance, predominantly localized on the lower extremities, particularly the shins. Subtypes include Schamberg disease, Majocchi's disease, Gougerot-Blum disease, Ducas and Kapetanakis pigmented purpura, and lichen aureus. Diagnosis relies primarily on clinical evaluation of skin lesions, with biopsy as a confirmatory tool. Although the exact cause of PPD remains unclear, capillary fragility and red blood cell extravasation are implicated. Treatment strategies for PPD aim to alleviate symptoms, considering the generally benign and chronic nature of the condition. As there is no standardized treatment, various methods with varying efficacy are employed. After searching SCOPUS and PubMed databases, we assessed 42 original articles to present current knowledge regarding therapy of PPD. This review will compare treatment approaches specifically in Schamberg disease and other manifestations of pigmented purpuric dermatoses.