Bioaccumulation and in vivo tracking of radiolabeled 4-nonylphenol in mice

4-Nonylphenol (4NP) is concerning due to its growing presence and endocrine-disrupting nature, raising concerns about its impact on health. In this study I-labeled 4NP was synthesized for tracing. Positron emission tomography imaging and biodistribution studies showed significant accumulation in var...

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Bibliographic Details
Published in:RSC advances 2024-03, Vol.14 (12), p.8578-8582
Main Authors: Mushtaq, Sajid, Kim, Soyeon, Bibi, Iqra, Park, Ji Ae, Yang, Ji-Ung, Park, Hyun, Kim, Jung Young
Format: Article
Language:English
Subjects:
Bioaccumulation
Chemistry
Emission analysis
In vivo methods and tests
Positron emission
Risk assessment
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Summary:4-Nonylphenol (4NP) is concerning due to its growing presence and endocrine-disrupting nature, raising concerns about its impact on health. In this study I-labeled 4NP was synthesized for tracing. Positron emission tomography imaging and biodistribution studies showed significant accumulation in various tissues after oral or intraperitoneal administration, emphasizing its intricate distribution and potential long-term effects, crucial for future risk assessments.
ISSN:2046-2069
2046-2069
DOI:10.1039/d3ra08743c