Research progress on the roles of dopamine and dopamine receptors in digestive system diseases

• Published in: Journal of cellular and molecular medicine 2024-04, Vol.28 (7), p.e18154-n/a
• Main Authors: Lu, Xianmin, Liu, Qi, Deng, Ya, Wu, Jiangbo, Mu, Xingyi, Yang, Xiaoxu, Zhang, Ting, Luo, Chen, Li, Zhuo, Tang, Siqi, Hu, Yanxia, Du, Qian, Xu, Jingyu, Xie, Rui
• Format: Article
• Language: English
• Subjects: Addictions; Adenosine; Blood circulation; Blood vessels; Brain research; brain‐gut axis; Digestive system; Digestive System Diseases; Dopamine; Dopamine - metabolism; dopamine receptor; Dopamine receptors; Esophageal cancer; Gastric cancer; Gastroesophageal reflux; Humans; Liver cancer; Medical prognosis; Mental disorders; Metastasis; Microbiota; Movement disorders; Nervous system; Neurodegenerative diseases; Neurological diseases; neurotransmitter; Neurotransmitter Agents; Neurotransmitters; Pancreatic cancer; Parkinson Disease - metabolism; Parkinson's disease; Physiology; Proteins; Receptors, Dopamine; Review; Reviews; Schizophrenia; Small intestine; Synapses; Ulcers
• ISSN: 1582-1838; 1582-4934; 1582-4934
• DOI: 10.1111/jcmm.18154

Dopamine (DA) is a neurotransmitter synthesized in the human body that acts on multiple organs throughout the body, reaching them through the blood circulation. Neurotransmitters are special molecules that act as messengers by binding to receptors at chemical synapses between neurons. As ligands, they mainly bind to corresponding receptors on central or peripheral tissue cells. Signalling through chemical synapses is involved in regulating the activities of various body systems. Lack of DA or a decrease in DA levels in the brain can lead to serious diseases such as Parkinson's disease, schizophrenia, addiction and attention deficit disorder. It is widely recognized that DA is closely related to neurological diseases. As research on the roles of brain‐gut peptides in human physiology and pathology has deepened in recent years, the regulatory role of neurotransmitters in digestive system diseases has gradually attracted researchers' attention, and research on DA has expanded to the field of digestive system diseases. This review mainly elaborates on the research progress on the roles of DA and DRs related to digestive system diseases. Starting from the biochemical and pharmacological properties of DA and DRs, it discusses the therapeutic value of DA‐ and DR‐related drugs for digestive system diseases.