Research progress on the roles of dopamine and dopamine receptors in digestive system diseases

Dopamine (DA) is a neurotransmitter synthesized in the human body that acts on multiple organs throughout the body, reaching them through the blood circulation. Neurotransmitters are special molecules that act as messengers by binding to receptors at chemical synapses between neurons. As ligands, th...

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Published in:Journal of cellular and molecular medicine 2024-04, Vol.28 (7), p.e18154-n/a
Main Authors: Lu, Xianmin, Liu, Qi, Deng, Ya, Wu, Jiangbo, Mu, Xingyi, Yang, Xiaoxu, Zhang, Ting, Luo, Chen, Li, Zhuo, Tang, Siqi, Hu, Yanxia, Du, Qian, Xu, Jingyu, Xie, Rui
Format: Article
Language:English
Subjects:
Addictions
Adenosine
Blood circulation
Blood vessels
Brain research
brain‐gut axis
Digestive system
Digestive System Diseases
Dopamine
Dopamine - metabolism
dopamine receptor
Dopamine receptors
Esophageal cancer
Gastric cancer
Gastroesophageal reflux
Humans
Liver cancer
Medical prognosis
Mental disorders
Metastasis
Microbiota
Movement disorders
Nervous system
Neurodegenerative diseases
Neurological diseases
neurotransmitter
Neurotransmitter Agents
Neurotransmitters
Pancreatic cancer
Parkinson Disease - metabolism
Parkinson's disease
Physiology
Proteins
Receptors, Dopamine
Review
Reviews
Schizophrenia
Small intestine
Synapses
Ulcers
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container_title Journal of cellular and molecular medicine
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creator Lu, Xianmin
Liu, Qi
Deng, Ya
Wu, Jiangbo
Mu, Xingyi
Yang, Xiaoxu
Zhang, Ting
Luo, Chen
Li, Zhuo
Tang, Siqi
Hu, Yanxia
Du, Qian
Xu, Jingyu
Xie, Rui
description Dopamine (DA) is a neurotransmitter synthesized in the human body that acts on multiple organs throughout the body, reaching them through the blood circulation. Neurotransmitters are special molecules that act as messengers by binding to receptors at chemical synapses between neurons. As ligands, they mainly bind to corresponding receptors on central or peripheral tissue cells. Signalling through chemical synapses is involved in regulating the activities of various body systems. Lack of DA or a decrease in DA levels in the brain can lead to serious diseases such as Parkinson's disease, schizophrenia, addiction and attention deficit disorder. It is widely recognized that DA is closely related to neurological diseases. As research on the roles of brain‐gut peptides in human physiology and pathology has deepened in recent years, the regulatory role of neurotransmitters in digestive system diseases has gradually attracted researchers' attention, and research on DA has expanded to the field of digestive system diseases. This review mainly elaborates on the research progress on the roles of DA and DRs related to digestive system diseases. Starting from the biochemical and pharmacological properties of DA and DRs, it discusses the therapeutic value of DA‐ and DR‐related drugs for digestive system diseases.
doi_str_mv 10.1111/jcmm.18154
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Neurotransmitters are special molecules that act as messengers by binding to receptors at chemical synapses between neurons. As ligands, they mainly bind to corresponding receptors on central or peripheral tissue cells. Signalling through chemical synapses is involved in regulating the activities of various body systems. Lack of DA or a decrease in DA levels in the brain can lead to serious diseases such as Parkinson's disease, schizophrenia, addiction and attention deficit disorder. It is widely recognized that DA is closely related to neurological diseases. As research on the roles of brain‐gut peptides in human physiology and pathology has deepened in recent years, the regulatory role of neurotransmitters in digestive system diseases has gradually attracted researchers' attention, and research on DA has expanded to the field of digestive system diseases. This review mainly elaborates on the research progress on the roles of DA and DRs related to digestive system diseases. 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subjects Addictions
Adenosine
Blood circulation
Blood vessels
Brain research
brain‐gut axis
Digestive system
Digestive System Diseases
Dopamine
Dopamine - metabolism
dopamine receptor
Dopamine receptors
Esophageal cancer
Gastric cancer
Gastroesophageal reflux
Humans
Liver cancer
Medical prognosis
Mental disorders
Metastasis
Microbiota
Movement disorders
Nervous system
Neurodegenerative diseases
Neurological diseases
neurotransmitter
Neurotransmitter Agents
Neurotransmitters
Pancreatic cancer
Parkinson Disease - metabolism
Parkinson's disease
Physiology
Proteins
Receptors, Dopamine
Review
Reviews
Schizophrenia
Small intestine
Synapses
Ulcers
title Research progress on the roles of dopamine and dopamine receptors in digestive system diseases
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