Cryopreservation of mouse thymus depletes thymocytes but supports immune reconstitution on transplantation

Cryopreservation of mouse thymus depletes donor thymocytes but preserves thymus function when transplanted after thawing into athymic mice. No differences in immune reconstitution were observed between fresh and frozen/thawed transplants suggesting that donor thymocyte depletion does not affect outc...

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Bibliographic Details
Published in:European journal of immunology 2023-12, Vol.53 (12), p.e2350546-n/a
Main Authors: Chawda, Mira M., Ross, Susan, Lau, Ching‐In, Yánez, Diana C., Rowell, Jasmine, Kilbride, Peter, Crompton, Tessa
Format: Article
Language:English
Subjects:
Animals
Clinical immunology
Cryopreservation
Humans
Immune Reconstitution
Mice
Thawing
Thymocytes
Thymopoiesis
Thymus
Thymus Gland
Thymus transplantation
Transplantation
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Summary:Cryopreservation of mouse thymus depletes donor thymocytes but preserves thymus function when transplanted after thawing into athymic mice. No differences in immune reconstitution were observed between fresh and frozen/thawed transplants suggesting that donor thymocyte depletion does not affect outcome. Thus, cryopreservation of thymus may improve outcomes in thymus transplant patients.
ISSN:0014-2980
1521-4141
DOI:10.1002/eji.202350546