Non-alcoholic fatty liver disease prevalence in Australia has risen over 15 years in conjunction with increased prevalence of obesity and reduction in healthy lifestyle

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver condition globally. The aim of this study was to evaluate the change in age- and sex-standardized prevalence of NAFLD in regional Victoria over a 15-year period and explore the underlying factors associated with differences over t...

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Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2023-10, Vol.38 (10), p.1823-1831
Main Authors: Vaz, Karl, Kemp, William, Majeed, Ammar, Lubel, John, Magliano, Dianna J, Glenister, Kristen M, Bourke, Lisa, Simmons, David, Roberts, Stuart K
Format: Article
Language:English
Subjects:
Adolescent
Age
Body Mass Index
Cross-Sectional Studies
Fatty liver
Female
Fibrosis
Healthy Lifestyle
Hepatitis
Humans
Liver diseases
Male
Non-alcoholic Fatty Liver Disease - complications
Non-alcoholic Fatty Liver Disease - epidemiology
Non-alcoholic Fatty Liver Disease - prevention & control
Obesity
Obesity - complications
Obesity - epidemiology
Original ‐ Hepatology (Clinical)
Prevalence
Risk Factors
Sex
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Summary:Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver condition globally. The aim of this study was to evaluate the change in age- and sex-standardized prevalence of NAFLD in regional Victoria over a 15-year period and explore the underlying factors associated with differences over time. Repeated comparative cross-sectional studies in four towns in regional Victoria, Australia. Individuals randomly selected from households from residential address lists from local government organizations in 2001-2003 (CrossRoads I [CR1]) and 2016-2018 (CrossRoads II [CR2]) with 1040 (99%) and 704 (94%) participants from CR1 and CR2 having complete data for analysis. Primary outcome was change in prevalence estimates of NAFLD (defined by a fatty liver index ≥ 60 in the absence of excess alcohol and viral hepatitis) between 2003 and 2018. Crude prevalence of NAFLD increased from 32.7% to 38.8% (P 
ISSN:0815-9319
1440-1746
DOI:10.1111/jgh.16314