Invasive fungal infections and oomycoses in cats: 1. Diagnostic approach

Clinical relevance: In contrast to superficial fungal infections, such as dermatophytosis, invasive fungal infections (IFIs) are characterised by penetration of tissues by fungal elements. Disease can spread locally within a region or can disseminate haematogenously or via the lymphatics. The enviro...

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Bibliographic Details
Published in:Journal of Feline Medicine and Surgery 2024-01, Vol.26 (1), p.1098612X231219696-1098612X231219696
Main Authors: Barrs, Vanessa R, Bęczkowski, Paweł M, Talbot, Jessica J, Hobi, Stefan, Teoh, Shu Ning, Hernandez Muguiro, Daniela, Shubitz, Lisa F, Sandy, Jeanine
Format: Article
Language:English
Subjects:
Animals
Antifungal Agents - therapeutic use
Cat Diseases - diagnosis
Cat Diseases - drug therapy
Cats
Coccidioidomycosis - veterinary
Dermatomycoses - veterinary
Histoplasmosis - veterinary
Invasive Fungal Infections - veterinary
Review
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Summary:Clinical relevance: In contrast to superficial fungal infections, such as dermatophytosis, invasive fungal infections (IFIs) are characterised by penetration of tissues by fungal elements. Disease can spread locally within a region or can disseminate haematogenously or via the lymphatics. The environment is the most common reservoir of infection. Since fungal spores are airborne, indoor cats are also susceptible to IFIs. Some environmental fungi are ubiquitous and present globally, while others are endemic or hyperendemic within specific geographic regions. Zoonotic pathogens include Microsporum canis, Sporothrix schenckii and Sporothrix brasiliensis. Aim: In the first of a two-part article series, the approach to the investigation of feline IFIs and oomycoses is reviewed. As well as tips for diagnosis, and information on the ecological niche and distribution of fungal pathogens, the review covers clinical presentation of the most common IFIs, including cryptococcosis, histoplasmosis, blastomycosis, coccidioidomycosis, sporotrichosis, phaeohyphomycosis, aspergillosis and dermatophytic pseudomycetoma, as well as the oomycoses pythiosis, lagenidiosis and paralagenidiosis. In Part 2, the spectrum of activity, mechanisms of action, pharmacokinetic and pharmacodynamic properties and adverse effects of antifungal drugs are reviewed, and the treatment and prognosis for specific IFIs and oomycoses are discussed. Evidence base: The review draws on published evidence and the authors' combined expertise in feline medicine, mycology, dermatology, clinical pathology and anatomical pathology.
ISSN:1098-612X
1532-2750
DOI:10.1177/1098612X231219696