Solvent-Mediated Polymorphic Transformations in Molten Polymers: The Account of Acetaminophen

Solvent-mediated polymorphic transformations (SMPTs) employing nonconventional solvents (polymer melts) is an underexplored research topic that limits the application of polymer-based formulation processes. Acetaminophen (ACM), a widely studied active pharmaceutical ingredient (API), is known to pre...

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Bibliographic Details
Published in:Molecular pharmaceutics 2022-07, Vol.19 (7), p.2183-2190
Main Authors: Hernández Espinell, José R., Toro, Verónica, Yao, Xin, Yu, Lian, Lopéz-Mejías, Vilmalí, Stelzer, Torsten
Format: Article
Language:English
Subjects:
Acetaminophen - chemistry
Ethanol
Polyethylene Glycols - chemistry
Polymers - chemistry
Solubility
Solvents - chemistry
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Summary:Solvent-mediated polymorphic transformations (SMPTs) employing nonconventional solvents (polymer melts) is an underexplored research topic that limits the application of polymer-based formulation processes. Acetaminophen (ACM), a widely studied active pharmaceutical ingredient (API), is known to present SMPTs spontaneously ( D PEGs = 5.32 × 10–11–8.36 × 10–14 m2/s). Ultimately, the study proves that the induction time for the SMPT can be tuned by understanding the dispersant’s physicochemical properties (i.e., η) and, thus, the D of the solute in the dispersant. This allows one to kinetically access and stabilize metastable forms or delay their transformations under given process conditions.
ISSN:1543-8384
1543-8392
DOI:10.1021/acs.molpharmaceut.2c00035