Immune response after rabies pre‐exposure prophylaxis and a booster dose in Australian bat carers

Periodic vaccination against rabies is essential for individuals at continuing risk of rabies exposure. There is limited evidence on long‐term immunogenicity after a 3‐dose intramuscular (3IM) pre‐exposure prophylaxis (PrEP) and single IM booster dose, thus current guideline recommendations differ i...

Full description

Saved in:
Bibliographic Details
Published in:Zoonoses and public health 2023-09, Vol.70 (6), p.465-472
Main Authors: Guo, Yihan, Mills, Deborah J., Lau, Colleen L., Mills, Christine, Furuya‐Kanamori, Luis
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibodies, Viral
Australia - epidemiology
Caregivers
Chiroptera
Defence mechanisms
Disease prevention
Exposure
Female
Humans
Immune response
Immune system
Immunity
immunization
immunization schedule
Immunization, Secondary - veterinary
Immunogenicity
Male
Original
Pre-Exposure Prophylaxis - methods
Preventive medicine
pre‐exposure prophylaxis
Prophylaxis
Public health
Rabies
Rabies - prevention & control
Rabies - veterinary
rabies vaccines
secondary
Serology
Vaccination
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Periodic vaccination against rabies is essential for individuals at continuing risk of rabies exposure. There is limited evidence on long‐term immunogenicity after a 3‐dose intramuscular (3IM) pre‐exposure prophylaxis (PrEP) and single IM booster dose, thus current guideline recommendations differ in the interval for serology tests following PrEP and boosters. This study investigated post‐PrEP and post‐booster persistence of antibodies in Australian bat carers. Bat carers who received 3IM PrEP/booster doses and had post‐PrEP/booster serology test results were included. The proportion of antibody‐negative (3 years after receiving one IM booster dose. Our findings support that a serology test should be performed 1 year after 3IM PrEP, followed by first booster if required. Rabies antibodies persist for many years after receiving the booster doses. The interval between subsequent serology tests and the first booster dose should be no longer than 3 years. Future studies are required to provide more insight into the most appropriate timing of subsequent boosters.
ISSN:1863-1959
1863-2378
DOI:10.1111/zph.13048