Peptides for trans‐blood–brain barrier delivery

Trans‐blood–brain barrier (BBB) delivery of therapeutic and diagnostic agents is a major challenge in the development of central nervous system (CNS) targeted radiopharmaceuticals. This review is an introduction to the use of peptides as delivery agents to transport cargos into the CNS. The most wid...

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Bibliographic Details
Published in:Journal of labelled compounds & radiopharmaceuticals 2023-07, Vol.66 (9), p.237-248
Main Authors: Blades, Reuben, Ittner, Lars M., Tietz, Ole
Format: Article
Language:English
Subjects:
Biological Transport
Blood-Brain Barrier
cell penetrating peptides
Cell-Penetrating Peptides - chemistry
Cell-Penetrating Peptides - therapeutic use
Central nervous system
Diagnostic agents
Diagnostic systems
Drug Delivery Systems
Peptides
Pharmacology
Radiopharmaceuticals
Special Issue Review
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Summary:Trans‐blood–brain barrier (BBB) delivery of therapeutic and diagnostic agents is a major challenge in the development of central nervous system (CNS) targeted radiopharmaceuticals. This review is an introduction to the use of peptides as delivery agents to transport cargos into the CNS. The most widely used BBB‐penetrating peptides are reviewed here, with a particular emphasis on the broad range of cargos delivered into the CNS using these. Cell‐penetrating peptides (CPPs) have been deployed as trans‐BBB delivery agents for some time; new developments in the CPP field offer exciting opportunities for the design of next generation trans‐BBB complexes. Many of the peptides highlighted here are ready to be combined with diagnostic and therapeutic radiopharmaceuticals to develop highly effective CNS‐targeted agents. Trans‐blood–brain barrier (BBB) delivery of therapeutic and diagnostic agents is a major challenge in the development of central nervous system (CNS) targeted radiopharmaceuticals. This review is an introduction to the use of peptides as delivery agents to transport cargos into the CNS. Peptides highlighted here are ready to be combined with diagnostic and therapeutic radiopharmaceuticals to develop the next generation of CNS‐targeted agents.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.4023