Personalized magnetic tentacles for targeted photothermal cancer therapy in peripheral lungs

Lung cancer remains one of the most life-threatening diseases and is currently managed through invasive approaches such as surgery, chemo- or radiotherapy. In this work, we introduce a novel method for the targeted delivery of a therapeutic laser for the treatment of tumors in peripheral areas of th...

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Bibliographic Details
Published in:Communications engineering 2023-07, Vol.2 (1), p.50, Article 50
Main Authors: Pittiglio, Giovanni, Chandler, James H., da Veiga, Tomas, Koszowska, Zaneta, Brockdorff, Michael, Lloyd, Peter, Barry, Katie L., Harris, Russell A., McLaughlan, James, Pompili, Cecilia, Valdastri, Pietro
Format: Article
Language:English
Subjects:
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Ablation
Biopsy
Bronchi
Bronchoscopy
Cancer therapies
Catheters
Computed tomography
Deformation
Design optimization
Engineering
Laser ablation
Lasers
Localization
Lung cancer
Medical imaging
Medical screening
Nanoparticles
Navigation
Optimization techniques
Radiation therapy
Robotics
Sensors
Shape control
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Summary:Lung cancer remains one of the most life-threatening diseases and is currently managed through invasive approaches such as surgery, chemo- or radiotherapy. In this work, we introduce a novel method for the targeted delivery of a therapeutic laser for the treatment of tumors in peripheral areas of the lungs. The approach uses a 2.4 mm diameter, ultra-soft, patient-specific magnetic catheter delivered from the end of a standard bronchoscope to reach the periphery of the lungs. Integrated shape sensing facilitates supervised autonomous full-shape control for precise navigation into the sub-segmental bronchi, and an embedded laser fiber allows for treatment via localized energy delivery. We report the complete navigation of eight primary lumina in the bronchi of an anatomically accurate phantom (developed from computed tomography (CT) data) and successful laser delivery for photothermal ablation. We further evaluate the approach in three diverse branches of excised cadaveric lungs, showing a mean improvement in navigation depth of 37% with less tissue displacement when compared to a standard semi-rigid catheter and navigation depth repeatability across all tests of
ISSN:2731-3395
2731-3395
DOI:10.1038/s44172-023-00098-9