Effect of platelet‐rich plasma on healing of lower extremity diabetic skin ulcers: A meta‐analysis

The aim of this research is to explore the therapeutic efficacy of platelet‐rich plasma (PRP) on the cutaneous ulceration of diabetes mellitus (DM). From the beginning of the database until January 2024, we looked through several databases to obtain randomised, controlled PRP studies to treat the wo...

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Bibliographic Details
Published in:International wound journal 2024-04, Vol.21 (4), p.e14856-n/a
Main Authors: Fang, Xiansong, Wang, Xiaoling, Hou, Ya, Zhou, Liang, Jiang, Yingjie, Wen, Xiaoyun
Format: Article
Language:English
Subjects:
amputation
complete wound closure
Original
PRP
wound infection
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Summary:The aim of this research is to explore the therapeutic efficacy of platelet‐rich plasma (PRP) on the cutaneous ulceration of diabetes mellitus (DM). From the beginning of the database until January 2024, we looked through several databases to obtain randomised, controlled PRP studies to treat the wound healing of DM in adult patients. The Cochrane Collaboration's Risk‐Of‐Bias Instrument was used to evaluate the risk of bias in randomised, controlled studies. Funnel plots, sensitivity analyses and Egger regression tests were employed to determine the reliability and effectiveness of the meta‐analyses. Depending on the degree of heterogeneity, a fixed or random effect model has been used. The statistical significance was determined to be below 0.05. Altogether 281 trials were collected from the database and entered into Endnote Software for screening, and 15 trials were analysed. It was found that PRP was associated with a higher rate of wound healing (OR, 3.23; 95% CI, 2.42, 4.31 p 
ISSN:1742-4801
1742-481X
DOI:10.1111/iwj.14856