Redox regulation in lifespan determination

One of the major challenges that remain in the fields of aging and lifespan determination concerns the precise roles that reactive oxygen species (ROS) play in these processes. ROS, including superoxide and hydrogen peroxide, are constantly generated as byproducts of aerobic metabolism, as well as i...

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Bibliographic Details
Published in:The Journal of biological chemistry 2024-03, Vol.300 (3), p.105761, Article 105761
Main Authors: Karagianni, Christina, Bazopoulou, Daphne
Format: Article
Language:English
Subjects:
aging
Aging - metabolism
Animals
Humans
JBC Reviews
lifespan
Longevity
longevity pathways
Oxidation-Reduction
Oxidative Stress
Reactive Oxygen Species - metabolism
redox signaling
ROS
stress
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Summary:One of the major challenges that remain in the fields of aging and lifespan determination concerns the precise roles that reactive oxygen species (ROS) play in these processes. ROS, including superoxide and hydrogen peroxide, are constantly generated as byproducts of aerobic metabolism, as well as in response to endogenous and exogenous cues. While ROS accumulation and oxidative damage were long considered to constitute some of the main causes of age-associated decline, more recent studies reveal a signaling role in the aging process. In fact, accumulation of ROS, in a spatiotemporal manner, can trigger beneficial cellular responses that promote longevity and healthy aging. In this review, we discuss the importance of timing and compartmentalization of external and internal ROS perturbations in organismal lifespan and the role of redox regulated pathways.
ISSN:0021-9258
1083-351X
1083-351X
DOI:10.1016/j.jbc.2024.105761