Biomarkers in the Diagnosis of Endometrial Precancers. Molecular Characteristics, Candidate Immunohistochemical Markers, and Promising Results of Three-Marker Panel: Current Status and Future Directions

Endometrial carcinoma stands as the most prevalent gynecological cancer and the fourth most common cancer affecting women. The incidence of endometrial cancer has been steadily increasing over the past decade, posing a significant threat to public health. The early detection of its precancers remain...

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Bibliographic Details
Published in:Cancers 2024-03, Vol.16 (6), p.1159
Main Authors: Niu, Shuang, Molberg, Kyle, Castrillon, Diego H, Lucas, Elena, Chen, Hao
Format: Article
Language:English
Subjects:
Adenocarcinoma
Biological markers
Biomarkers
Carcinoma
Care and treatment
Classification
Development and progression
Diagnosis
Endometrial cancer
Endometrium
Genetic aspects
Genomes
Gynecology
Hyperplasia
Lynch, Ed
Molecular genetics
Morphology
Mutation
Public health
Review
Reviews
Tumors
Uterine cancer
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Summary:Endometrial carcinoma stands as the most prevalent gynecological cancer and the fourth most common cancer affecting women. The incidence of endometrial cancer has been steadily increasing over the past decade, posing a significant threat to public health. The early detection of its precancers remains a critical and evolving concern to reduce mortality associated with endometrial carcinoma. In the last decade, our understanding of endometrial carcinoma and its precancers has advanced through systematic investigations into the molecular genetics of endometrial carcinoma and its precancers. In this review, we focus on advances in precancers associated with the endometrioid subtype, by far the most common histologic variant of endometrial adenocarcinoma. Recent investigations have led to the identification of new biomarkers, and the proposed incorporation of these biomarkers or biomarker panels into the diagnostic framework of endometrial carcinoma precancers. Here, we review these recent advances and their relevance to the histopathologic diagnosis of endometrial carcinoma precancers.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers16061159