Increasing age of multiple sclerosis onset from 1920 to 2022: a population-based study

Objective To study the age at onset of relapsing–remitting multiple sclerosis (RRMS) during the past century. Methods This is a population-based cohort study of persons diagnosed with RRMS in Hordaland, Møre, and Romsdal counties, Western Norway, from 1920 to 2022. Individual patient data were avail...

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Bibliographic Details
Published in:Journal of neurology 2024-04, Vol.271 (4), p.1610-1617
Main Authors: Habbestad, A., Willumsen, J. S., Aarseth, J. H., Grytten, N., Midgard, R., Wergeland, S., Myhr, K. M., Torkildsen, Ø.
Format: Article
Language:English
Subjects:
Age
Age composition
Diagnosis
Medicine
Medicine & Public Health
Multiple sclerosis
Neurology
Neuroradiology
Neurosciences
Original Communication
Population studies
Risk factors
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Summary:Objective To study the age at onset of relapsing–remitting multiple sclerosis (RRMS) during the past century. Methods This is a population-based cohort study of persons diagnosed with RRMS in Hordaland, Møre, and Romsdal counties, Western Norway, from 1920 to 2022. Individual patient data were available and assessed from previously conducted prevalence and incidence studies in addition to hospital records up until October 31, 2022. Participants were categorized according to onset period and analyzed for temporal trends in age at onset, time from onset to diagnosis, and distribution of onset over time. Results We identified 3364 persons with confirmed RRMS. The mean age at onset significantly increased ( p  
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-023-12047-9