Synchronous multiple primary neoplasms of the esophagus, rectosigmoid and central nervous system

• Published in: International journal of surgery case reports 2024-04, Vol.117, p.109566, Article 109566
• Main Authors: Jena, Suvendu Sekhar, Nundy, Samiran
• Format: Article
• Language: English
• Subjects: Case Report; Colorectal malignancy; Esophageal malignancy; MPN; Multiple primary neoplasm
• ISSN: 2210-2612; 2210-2612
• DOI: 10.1016/j.ijscr.2024.109566

Multiple primary neoplasms (MPN) are rare and can affect any system especially the upper aero-digestive system. They can be simultaneous, synchronous or metachronous. Their management depends on the individual organ system affected and simultaneous resection is possible as shown by T. Suzuki. We encountered a 77-year-old male who had had malena and constipation for 2 months and on investigation was found to have a rectosigmoid and an esophageal adenocarcinoma as well as a calcified lesion in the brain. He underwent surgery for the rectosigmoid growth only (according to the patient's preference) and received chemotherapy. Unfortunately, he developed acute intestinal obstruction after 2 cycles of chemotherapy and died. MPNS are defined as presence of two or more histologically distinct tumours in the same individual. It can be synchronous or metachronous. Various factors like genetic and environmental play crucial role in its development. Management of these depends up on the status of the patient, stage of disease. MPNS are rare but their rising trend suggests it should be kept in mind while working up a patient with any malignancy. •MPNs are defined as multiple tumours originating independently in a single individual.•The association of esophageal with colorectal adenocarcinoma is also rare with an incidence around 0.2% to 7.8% synchronously and 1 to 4.6% metachronously.•The management of MPNs is challenging as it often requires multimodal therapy including surgery, chemotherapy, and radiotherapy.