Discriminant Potential of the Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) in Greek Older Adults with Subjective Cognitive Decline and Mild Cognitive Impairment

• Published in: JAD reports 2024-03, Vol.8 (1), p.543-554
• Main Authors: Tsatali, Marianna, Moraitou, Despina, Gialaouzidis, Moses, Bakoglidou, Evaggelia, Psaltis, Vasilis, Bertzes, Natalia, Hassanin, Hany Ibrahim, Emmanouilidou, Eudokia, Totonidis, Michael, Frantzi, Nikoleta, Avdikou, Konstantina, Gavra, Andromachi, Diamantidou, Alexandra, Kapsali, Nikolina, Kouroundi, Eleni, Tsolaki, Magda
• Format: Article
• Language: English
• Subjects: Research Report
• ISSN: 2542-4823; 2542-4823
• DOI: 10.3233/ADR-230151

Background: Alzheimer’s Disease Assessment Scale Cognitive Subscale (ADAS-Cog) is a widely used screening tool for detecting older adults with Alzheimer’s disease among their cognitively healthy peers. A previous study in Greek population showed that ADAS-Cog-Greek (G) is a valid tool and can identify people with Alzheimer’s disease from older adult control group; however, there is no current data about whether ADAS-Cog can differentiate older adults with mild cognitive impairment (MCI) from those who have subjective cognitive decline (SCD). Objective: The current study aimed to examine the discriminant potential of ADAS-Cog-G in Greek older adults who meet the criteria for SCD or MCI. Methods: Four hundred eighty-two community-dwelling older adults, visitors of the Greek Alzheimer Association and Related Disorders, were enrolled in the current study. One hundred seventy-six of them met the criteria for SCD and three hundred six had MCI. Results: Path analysis applied to the data showed that age, as well as educational level affected ADAS-Cog-G performance. Results showed that the cut-off scores, which better discriminate people with SCD from MCI as well as their sensitivity and specificity values, were extracted in participants with high educational level (13 educational years