Primary Malignant Melanoma of the Esophagus Treated with Surgical Resection at an Early Stage

Abstract Introduction: Primary malignant melanoma of the esophagus is a very rare disease with a poor prognosis. We herein report a patient with primary malignant melanoma of the esophagus who underwent surgical resection. Case Presentation: A 73-year-old female underwent an upper gastrointestinal e...

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Published in:Case reports in gastroenterology 2024-01, Vol.18 (1), p.189-194
Main Authors: Yoneda, Akira, Ogata, Ryosuke, Ryu, Shintaro, Yoshino, Kyohei, Fukui, Saeko, Ikeda, Takahiro, Kitasato, Amane, Sugiyama, Nozomu, Takeshita, Hiroaki, Minami, Shigeki, Ito, Masahiro, Kuroki, Tamotsu
Format: Article
Language:English
Subjects:
Antigens
Biopsy
Case reports
Chemotherapy
Conflicts of interest
Endoscopy
Esophagus
Ethics
Immunotherapy
Literature reviews
Lymphatic system
malignant melanoma
Medical prognosis
Melanoma
Metastasis
Patients
Rare diseases
Single Case
Skin cancer
Squamous cell carcinoma
Surgery
surgical resection
Tomography
Tumors
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Summary:Abstract Introduction: Primary malignant melanoma of the esophagus is a very rare disease with a poor prognosis. We herein report a patient with primary malignant melanoma of the esophagus who underwent surgical resection. Case Presentation: A 73-year-old female underwent an upper gastrointestinal endoscopy during follow-up for colonic diverticulitis. An endoscopic examination and constructed radiography revealed a slightly elevated black pigmented lesion in the upper esophagus and a black pigmented area in the esophagogastric junction. Through a preoperative endoscopic biopsy, she was diagnosed with malignant melanoma of the esophagus. We performed thoracoscopy-assisted and laparoscopy-assisted subtotal esophagectomy with lymphadenectomy. The surgical specimens were subjected to immunohistochemical analysis, resulting in a diagnosis of malignant melanoma. The tumor cells were positive for Melan-A and HMB-45 diffusely, supporting that diagnosis. We performed surgical resection in a case of primary malignant melanoma of the esophagus, and the patient has remained disease free for 2 years since the surgery. Conclusion: Early diagnosis and radical resection may be essential for long-term survival in patients with malignant melanoma of the esophagus.
ISSN:1662-0631
1662-0631
DOI:10.1159/000538161