Soluble polyvinylpyrrolidone‐based microneedles loaded with Sanguis draconis and Salvia miltiorrhiza for treatment of diabetic wound healing

Background Nowadays, diabetic wound healing remains a crucial challenge due to their protracted and uncertain healing process. Traditional Chinese medicine (TCM) has demonstrated the therapeutic value of Sanguis draconis (SD)‐Salvia miltiorrhiza (SMR) Herb Pair in diabetic wound healing. However, ne...

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Published in:Skin research and technology 2024-04, Vol.30 (4), p.e13671-n/a
Main Authors: Tang, Jiangdong, Xu, Jiawei, Xu, Jianda, Fan, Zhenmin, Ye, Xia, Xia, Zhongyu, Guo, Meifeng
Format: Article
Language:English
Subjects:
angiogenesis
Blood flow
Diabetes
Diabetes mellitus
Diabetes Mellitus - drug therapy
diabetic foot ulcer
Drugs, Chinese Herbal
Flow velocity
Freeze drying
Herbal medicine
Humans
microneedle
Needles
Original
Plant extracts
Polyvinylpyrrolidone
Povidone
Salvia miltiorrhiza
Salviae miltiorrhizae Radix et Rhizoma
Sanguis draconis
Traditional Chinese medicine
Wound Healing
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Summary:Background Nowadays, diabetic wound healing remains a crucial challenge due to their protracted and uncertain healing process. Traditional Chinese medicine (TCM) has demonstrated the therapeutic value of Sanguis draconis (SD)‐Salvia miltiorrhiza (SMR) Herb Pair in diabetic wound healing. However, new administration modes are urgently needed for their convenient and wide‐ranging applications. Objective We propose a soluble polyvinylpyrrolidone‐based microneedle patch containing the herbal extracts of SD and SMR (MN‐SD@SMR) for diabetic wound healing. Methods The herbal extracts of SD and SMR are purification and concentration via traditional lyophilization. SD endowed MN‐SD@SMR with functions to improve high glycemic blood environment and migration of keratinocyte and fibroblast cells. Results SMR in MN‐SD@SMR could improve blood flow velocity and microcirculation in the wound area. The effectiveness of transdermal release and mechanical strengths of MN‐SD@SMR were verified. Conclusion Integrating the advantages of these purified herbal compositions, we demonstrated that MN‐SD@SMR had a positive healing effect on the wounds in vitro and vivo. These results indicate that soluble polyvinylpyrrolidone‐based microneedle patch containing the herbal extracts of SD and SMR has a promising application value due to their superior capability to promote diabetic wound healing.
ISSN:0909-752X
1600-0846
1600-0846
DOI:10.1111/srt.13671