Juvenile Papillomatosis of the Breast: a Report of Two Cases with Review of the literature

Background: Juvenile papillomatosis (JP) of the breast is a rare and benign proliferative disorder affecting young women. The affected patients tend to have an increased risk of breast cancer development during follow-up. Objective: This article aims to highlight a rare entity of breast disease, tha...

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Bibliographic Details
Published in:Medicinski arhiv 2024, Vol.78 (2), p.170-173
Main Authors: Qurashi, Mariam, Ibrahim, Arwa, ElSharkawy, Tarek, Nemer, Areej, Alhaddad, Hiyam, Hadi, Maha
Format: Article
Language:English
Subjects:
Biopsy
Breast cancer
Breast diseases
Case Report
Case reports
Consent
Cysts
Epidermal growth factor
Family medical history
Females
Hyperplasia
Literature reviews
Magnetic resonance imaging
Mammography
Pathology
Patients
Surgery
Surveillance
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Summary:Background: Juvenile papillomatosis (JP) of the breast is a rare and benign proliferative disorder affecting young women. The affected patients tend to have an increased risk of breast cancer development during follow-up. Objective: This article aims to highlight a rare entity of breast disease, that harbor risk of breast cancer. Case Presentation: Here, we present 2 cases of JP in young females; the first case is a 13 year-old presented with spontaneous nipple discharge, while the other patient is a 24 year-old presented with a right breast lump. Both patients had a total excision of the breast lesions, revealing JP at histology. Discussion: Juvenile Papillomatosis is considered a clinicopathological entity and is usually misdiagnosed as fibroadenoma clinically and radiologically, which requires histological correlation. The histologic findings are well-defined (hyperplasia, papillomatosis, and multiple cysts with foamy histiocytes).The controversy in management between surgery and observation is because of insufficient knowledge about the direct relationship between JP and subsequent cancer. Conclusion: Considering the risk of developing breast cancer in JP, enrolling patients and their families in a close follow-up and surveillance program is crucial.
ISSN:0350-199X
1986-5961
DOI:10.5455/medarh.2024.78.170-173