Prognostic and predictive role of immune microenvironment in colorectal cancer

Colorectal cancer (CRC) represents a molecularly heterogeneous disease and one of the most frequent causes of cancer-related death worldwide. The traditional classification of CRC is based on pathomorphological and molecular characteristics of tumor cells (mucinous, ring-cell carcinomas, ), analysis...

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Published in:World journal of gastrointestinal oncology 2024-03, Vol.16 (3), p.643-652
Main Authors: Kuznetsova, Olesya, Fedyanin, Mikhail, Zavalishina, Larisa, Moskvina, Larisa, Kuznetsova, Olga, Lebedeva, Alexandra, Tryakin, Alexey, Kireeva, Galina, Borshchev, Gleb, Tjulandin, Sergei, Ignatova, Ekaterina
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Language:English
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Summary:Colorectal cancer (CRC) represents a molecularly heterogeneous disease and one of the most frequent causes of cancer-related death worldwide. The traditional classification of CRC is based on pathomorphological and molecular characteristics of tumor cells (mucinous, ring-cell carcinomas, ), analysis of mechanisms of carcinogenesis involved (chromosomal instability, microsatellite instability, CpG island methylator phenotype) and mutational statuses of commonly altered genes (KRAS, NRAS, BRAF, APC, ), as well as expression signatures (CMS 1-4). It is also suggested that the tumor microenvironment is a key player in tumor progression and metastasis in CRC. According to the latest data, the immune microenvironment can also be predictive of the response to immune checkpoint inhibitors. In this review, we highlight how the immune environment influences CRC prognosis and sensitivity to systemic therapy.
ISSN:1948-5204
1948-5204
DOI:10.4251/wjgo.v16.i3.643