Incorporating sarcopenia and inflammation with radiation therapy in patients with hepatocellular carcinoma treated with nivolumab

Background We investigated the combined effects of sarcopenia and inflammation on outcomes in patients with HCC treated with nivolumab. Materials and Methods We reviewed 102 patients treated with nivolumab between 2017 and 2018. Sarcopenia was diagnosed when the L3 skeletal muscle indices were 

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Bibliographic Details
Published in:Cancer Immunology, Immunotherapy Immunotherapy, 2021-06, Vol.70 (6), p.1593-1603
Main Authors: Kim, Nalee, Yu, Jeong Il, Park, Hee Chul, Yoo, Gyu Sang, Choi, Changhoon, Hong, Jung Yong, Lim, Ho Yeong, Lee, Jeeyun, Choi, Moon Seok, Lee, Jung Eun, Kim, Kyunga
Format: Article
Language:English
Subjects:
Aged
Antineoplastic Agents, Immunological - therapeutic use
Bilirubin
Biomarkers, Tumor - analysis
Cancer Research
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - therapy
Cell number
Female
Follow-Up Studies
Hepatocellular carcinoma
Humans
Immunology
Immunotherapy
Inflammation
Inflammation - physiopathology
Leukocytes (neutrophilic)
Liver cancer
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Liver Neoplasms - therapy
Lymphocytes
Lymphocytes - pathology
Lymphopenia
Male
Medicine
Medicine & Public Health
Middle Aged
Monoclonal antibodies
Neutrophils - pathology
Nivolumab - therapeutic use
Oncology
Original
Original Article
Prognosis
Radiation therapy
Radiotherapy - methods
Retrospective Studies
Risk factors
Sarcopenia
Sarcopenia - physiopathology
Skeletal muscle
Survival Rate
Targeted cancer therapy
α-Fetoprotein
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Description
Summary:Background We investigated the combined effects of sarcopenia and inflammation on outcomes in patients with HCC treated with nivolumab. Materials and Methods We reviewed 102 patients treated with nivolumab between 2017 and 2018. Sarcopenia was diagnosed when the L3 skeletal muscle indices were 
ISSN:0340-7004
1432-0851
DOI:10.1007/s00262-020-02794-3