Drug-Induced Autoimmune Hepatitis: An Unusual Adverse Event of Atorvastatin Therapy

Drug-induced autoimmune hepatitis (AIH) is characterized by acute or chronic hepatic injury coupled with autoantibody development, hypertransaminasemia, and idiopathic AIH features on liver biopsy. Atorvastatin-induced AIH is a rare but well-documented life-threatening adverse event. We report a cas...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2024-03, Vol.16 (3), p.e55809
Main Authors: Patel, Mitwa, Fattah, Abdul, Hussaini, Helai, Maneesha, Fnu, Ahmed, Zahoor
Format: Article
Language:English
Subjects:
Allergy/Immunology
Antibodies
Biopsy
Case reports
Drug dosages
Drug withdrawal
Enzymes
Gastroenterology
Hepatitis
Internal Medicine
Liver
Medicine
Metabolic disorders
Phosphatase
Serology
Statins
Steroids
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Summary:Drug-induced autoimmune hepatitis (AIH) is characterized by acute or chronic hepatic injury coupled with autoantibody development, hypertransaminasemia, and idiopathic AIH features on liver biopsy. Atorvastatin-induced AIH is a rare but well-documented life-threatening adverse event. We report a case of atorvastatin-induced AIH in a 57-year-old female who presented with worsening fatigue, jaundice, and deranged liver function tests. She had been prescribed atorvastatin 20 mg daily three months prior. Her clinical presentation, imaging findings, and serological testing were suggestive of drug-induced AIH. A liver biopsy confirmed a drug-induced autoimmune picture, and she was diagnosed with atorvastatin-induced AIH after ruling out all other possible causes. Her clinical presentation and liver enzymes improved after prolonged treatment with prednisone.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.55809