Activity of isoflavone in managing polycystic ovary syndrome symptoms (Review)

Polycystic ovary syndrome (PCOS), a hormonal and metabolic disorder manifested in women of reproductive age, is still being treated using drugs with side effects. As an alternative to these drugs, isoflavone, also identified as phytoestrogen, has anti-PCOS activity. Isoflavone can help relieve PCOS...

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Bibliographic Details
Published in:Biomedical reports 2024-05, Vol.20 (5), p.80-80, Article 80
Main Authors: Raihanah, Cut, Sukrasno, Sukrasno, Kurniati, Neng Fisheri
Format: Article
Language:English
Subjects:
Abdomen
Acne
Alopecia
Androgens
Antioxidants
Baldness
Birth control
Clinical trials
Drugs
Enzymes
Estrogens
Females
Hormones
In vivo methods and tests
Inflammation
Insulin resistance
Isoflavones
Medical research
Medicine, Experimental
Menstrual cycle
Menstruation
Metabolic disorders
Metabolism
Obesity
Ovaries
Oxidative stress
Phytoestrogens
Polycystic ovary syndrome
Review
Side effects
Stein-Leventhal syndrome
Testosterone
Weight control
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Description
Summary:Polycystic ovary syndrome (PCOS), a hormonal and metabolic disorder manifested in women of reproductive age, is still being treated using drugs with side effects. As an alternative to these drugs, isoflavone, also identified as phytoestrogen, has anti-PCOS activity. Isoflavone can help relieve PCOS symptoms by lowering the level of testosterone, which causes hyperandrogenism, thereby normalizing the menstrual cycle and restoring normal ovarian morphology. Furthermore, isoflavone influences the improvement of the metabolic profile, which changes because of PCOS, as well as the reduction of inflammatory markers and oxidative stress. However, both significant and non-significant results have been generated on the activity of isoflavones in PCOS. The present review aims to discuss the existing literature on the effect of isoflavone on PCOS symptoms based on and clinical trial studies.
ISSN:2049-9434
2049-9442
DOI:10.3892/br.2024.1768