Relationship Between Short-chain Fatty Acids and Parkinson’s Disease: A Review from Pathology to Clinic

Parkinson’s disease (PD) is a complicated neurodegenerative disease, characterized by the accumulation of α-synuclein (α-syn) in Lewy bodies and neurites, and massive loss of midbrain dopamine neurons. Increasing evidence suggests that gut microbiota and microbial metabolites are involved in the dev...

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Bibliographic Details
Published in:Neuroscience bulletin 2024-04, Vol.40 (4), p.500-516
Main Authors: Duan, Wen-Xiang, Wang, Fen, Liu, Jun-Yi, Liu, Chun-Feng
Format: Article
Language:English
Subjects:
Anatomy
Anesthesiology
Biomedical and Life Sciences
Biomedicine
Brain - pathology
Fatty Acids, Volatile - metabolism
Human Physiology
Humans
Mesencephalon - metabolism
Neurodegenerative Diseases - pathology
Neurology
Neurosciences
Pain Medicine
Parkinson Disease - metabolism
Review
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Summary:Parkinson’s disease (PD) is a complicated neurodegenerative disease, characterized by the accumulation of α-synuclein (α-syn) in Lewy bodies and neurites, and massive loss of midbrain dopamine neurons. Increasing evidence suggests that gut microbiota and microbial metabolites are involved in the development of PD. Among these, short-chain fatty acids (SCFAs), the most abundant microbial metabolites, have been proven to play a key role in brain-gut communication. In this review, we analyze the role of SCFAs in the pathology of PD from multiple dimensions and summarize the alterations of SCFAs in PD patients as well as their correlation with motor and non-motor symptoms. Future research should focus on further elucidating the role of SCFAs in neuroinflammation, as well as developing novel strategies employing SCFAs and their derivatives to treat PD.
ISSN:1673-7067
1995-8218
DOI:10.1007/s12264-023-01123-9