Extracellular L-Asparaginase Synthesis Bacillus niacin Isolation, Optimization, and Characterization from Marine Saltern Sediment Sources

• Published in: Avicenna journal of medical biotechnology 2024-01, Vol.16 (1), p.40-48
• Main Authors: Wahab, Mugip Rahaman Abdul, Palaniyandi, Thirunavukkarasu, Wyson, John, Sivaji, Asha, Thamada, Swarnakala
• Format: Article
• Language: English
• Subjects: Original
• ISSN: 2008-2835; 2008-4625
• DOI: 10.18502/ajmb.v16i1.14170

Asparagine is an amino acid that can be converted into aspartic acid and ammonia by the enzyme L-asparaginase. Some forms of cancer, such Acute Lymphoblastic Leukaemia (ALL) and Non-Hodgkin Lymphoma (NHL), respond well to this enzyme when employed as a chemotherapeutic drug. The purpose of this research was to find bacteria that can manufacture the enzymes L-asparaginasein marine slattern sediment which can be employed in commercial and industrial scale production. All of the strains were identified as . by biochemical and molecular testing. The strain belongs to the genus, according to nutritional, biochemical, PCR and 16srRNA sequencing data. According to the findings of this research, have the potential to create a substance that is helpful in a variety of medical applications. The results of this study hint to the possibility that bacteria have the ability to produce antimicrobial compounds, which have the potential to be successful in a wide variety of environments. Numerous opportunities may arise for researchers interested in utilizing the medical potential of enzyme-producing bacteria if they are successfully isolated and screened from aquatic and terrestrial habitats.