The recipient metabolome explains the asymmetric ovarian impact on fetal sex development after embryo transfer in cattle

In cattle, lateral asymmetry affects ovarian function and embryonic sex, but the underlying molecular mechanisms remain unknown. The plasma metabolome of recipients serves to predict pregnancy after embryo transfer (ET). Thus, the aim of this study was to investigate whether the plasma metabolome ex...

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Bibliographic Details
Published in:Journal of animal science 2024-01, Vol.102
Main Authors: Gimeno, Isabel, Salvetti, Pascal, Carrocera, Susana, Gatien, Julie, Le Bourhis, Daniel, Gómez, Enrique
Format: Article
Language:English
Subjects:
Animals
Cattle
Embryo Transfer - veterinary
Female
Hippurates
Male
Metabolome
Ovary
Phenylalanine
Pregnancy
Pregnancy Rate
Propionates
Reproduction
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Summary:In cattle, lateral asymmetry affects ovarian function and embryonic sex, but the underlying molecular mechanisms remain unknown. The plasma metabolome of recipients serves to predict pregnancy after embryo transfer (ET). Thus, the aim of this study was to investigate whether the plasma metabolome exhibits distinct lateral patterns according to the sex of the fetus carried by the recipient and the active ovary side (AOS), i.e., the right ovary (RO) or the left ovary (LO). We analyzed the plasma of synchronized recipients by 1H+NMR on day 0 (estrus, n = 366) and day 7 (hours prior to ET; n = 367). Thereafter, a subset of samples from recipients that calved female (n = 50) or male (n = 69) was used to test the effects of embryonic sex and laterality on pregnancy establishment. Within the RO, the sex ratio of pregnancies carried was biased toward males. Significant differences (P 
ISSN:0021-8812
1525-3163
DOI:10.1093/jas/skae081