The hypoxic ventilatory response and hypoxic burden are predictors of the magnitude of ventilatory long-term facilitation in humans

Mild intermittent hypoxia initiates progressive augmentation (PA) and ventilatory long-term facilitation (vLTF) in humans. The magnitude of these forms of plasticity might be influenced by anthropometric and physiological variables, as well as protocol elements. However, the impact of many of these...

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Bibliographic Details
Published in:The Journal of physiology 2023-10, Vol.601 (20), p.4611-4623
Main Authors: Panza, Gino S, Kissane, Dylan M, Puri, Shipra, Mateika, Jason H
Format: Article
Language:English
Subjects:
Humans
Hypoxia
Hypoxia - metabolism
Physiology
Plasticity
Protocol
Pulmonary Ventilation - physiology
Variables
Ventilatory behavior
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Summary:Mild intermittent hypoxia initiates progressive augmentation (PA) and ventilatory long-term facilitation (vLTF) in humans. The magnitude of these forms of plasticity might be influenced by anthropometric and physiological variables, as well as protocol elements. However, the impact of many of these variables on the magnitude of respiratory plasticity has not been established in humans. A meta-analysis was completed using anthropometric and physiological variables obtained from 124 participants that completed one of three intermittent hypoxia protocols. Simple correlations between the aggregate variables and the magnitude of PA and vLTF standardized to baseline was completed. Thereafter, the variables correlated to PA or vLTF were input into a multilinear regression equation. Baseline measures of the hypoxic ventilatory response was the sole predictor of PA (R = 0.370, P = 0.012). Similarly, this variable along with the hypoxic burden predicted the magnitude of vLTF (R = 0.546, P 
ISSN:0022-3751
1469-7793
1469-7793
DOI:10.1113/JP285192