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Does Programmed Cell Death 1 Ligand (Pd-L1) Expression Predict Recurrence in Women With Endometrioma?
The study aimed to evaluate whether there is a difference in the expression of programmed cell death 1 ligand (PD-L1) in the cell lining of endometrioma between cases with and without recurrent disease. Additionally, we sought to assess the effect of cyst size and serum CA125 level on the expression...
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Published in: | Curēus (Palo Alto, CA) CA), 2024-03, Vol.16 (3), p.e56262-e56262 |
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description | The study aimed to evaluate whether there is a difference in the expression of programmed cell death 1 ligand (PD-L1) in the cell lining of endometrioma between cases with and without recurrent disease. Additionally, we sought to assess the effect of cyst size and serum CA125 level on the expression of PD-L1 staining. The pathological specimens were immunohistochemically stained for PD-L1 in women who underwent surgery for endometrioma. All patients were evaluated to confirm if their endometriomas had recurred or not. A total of 36 patients who underwent surgery for endometrioma were included. The study population was divided into two groups according to their recurrence status. The study group (having recurrence) (n=12) and the control group (having no recurrence) (n=24) were compared regarding their demographic and clinical characteristics and PD-L1 staining. PD-L1 staining and the intensity of PD-L1 staining did not differ between the patients with and without recurrence. No variable, including parity, cyst size, serum CA125 level, and PD-L1 staining, was found to be significant in determining recurrence. No significant difference was found between the groups with and without PD-L1 staining in terms of cyst size and serum CA125 level. Although we have shown that PD-L1 expression could not be used for the prediction of recurrence, further studies are needed to assess this issue and to guide the development of new immunotherapeutic agents on this basis. |
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Additionally, we sought to assess the effect of cyst size and serum CA125 level on the expression of PD-L1 staining. The pathological specimens were immunohistochemically stained for PD-L1 in women who underwent surgery for endometrioma. All patients were evaluated to confirm if their endometriomas had recurred or not. A total of 36 patients who underwent surgery for endometrioma were included. The study population was divided into two groups according to their recurrence status. The study group (having recurrence) (n=12) and the control group (having no recurrence) (n=24) were compared regarding their demographic and clinical characteristics and PD-L1 staining. PD-L1 staining and the intensity of PD-L1 staining did not differ between the patients with and without recurrence. No variable, including parity, cyst size, serum CA125 level, and PD-L1 staining, was found to be significant in determining recurrence. No significant difference was found between the groups with and without PD-L1 staining in terms of cyst size and serum CA125 level. Although we have shown that PD-L1 expression could not be used for the prediction of recurrence, further studies are needed to assess this issue and to guide the development of new immunotherapeutic agents on this basis.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.56262</identifier><identifier>PMID: 38623124</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Antigens ; Cancer ; Cell death ; Chi-square test ; Cohort analysis ; Comorbidity ; Cysts ; Endometriosis ; Hysterectomy ; Independent sample ; Infertility ; Laparoscopy ; Laparotomy ; Ligands ; Menstruation ; Obstetrics/Gynecology ; Ovaries ; Parity ; Pathogenesis ; Pathology ; Patients ; Regression analysis ; Sexual disorders ; Urological surgery ; Variables ; Womens health</subject><ispartof>Curēus (Palo Alto, CA), 2024-03, Vol.16 (3), p.e56262-e56262</ispartof><rights>Copyright © 2024, Goksever Celik et al.</rights><rights>Copyright © 2024, Goksever Celik et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2024, Goksever Celik et al. 2024 Goksever Celik et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c300t-2ebcfe26a0c067c5b9944497119182d3781c3a6464331f6e02bc304be1ed25543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3049787263/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3049787263?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38623124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goksever Celik, Hale</creatorcontrib><creatorcontrib>Celik, Engin</creatorcontrib><creatorcontrib>Uhri, Mehmet</creatorcontrib><creatorcontrib>Bastu, Ercan</creatorcontrib><creatorcontrib>Gungor, Mete</creatorcontrib><creatorcontrib>Buyru, Faruk</creatorcontrib><title>Does Programmed Cell Death 1 Ligand (Pd-L1) Expression Predict Recurrence in Women With Endometrioma?</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>The study aimed to evaluate whether there is a difference in the expression of programmed cell death 1 ligand (PD-L1) in the cell lining of endometrioma between cases with and without recurrent disease. Additionally, we sought to assess the effect of cyst size and serum CA125 level on the expression of PD-L1 staining. The pathological specimens were immunohistochemically stained for PD-L1 in women who underwent surgery for endometrioma. All patients were evaluated to confirm if their endometriomas had recurred or not. A total of 36 patients who underwent surgery for endometrioma were included. The study population was divided into two groups according to their recurrence status. The study group (having recurrence) (n=12) and the control group (having no recurrence) (n=24) were compared regarding their demographic and clinical characteristics and PD-L1 staining. PD-L1 staining and the intensity of PD-L1 staining did not differ between the patients with and without recurrence. No variable, including parity, cyst size, serum CA125 level, and PD-L1 staining, was found to be significant in determining recurrence. No significant difference was found between the groups with and without PD-L1 staining in terms of cyst size and serum CA125 level. Although we have shown that PD-L1 expression could not be used for the prediction of recurrence, further studies are needed to assess this issue and to guide the development of new immunotherapeutic agents on this basis.</description><subject>Antigens</subject><subject>Cancer</subject><subject>Cell death</subject><subject>Chi-square test</subject><subject>Cohort analysis</subject><subject>Comorbidity</subject><subject>Cysts</subject><subject>Endometriosis</subject><subject>Hysterectomy</subject><subject>Independent sample</subject><subject>Infertility</subject><subject>Laparoscopy</subject><subject>Laparotomy</subject><subject>Ligands</subject><subject>Menstruation</subject><subject>Obstetrics/Gynecology</subject><subject>Ovaries</subject><subject>Parity</subject><subject>Pathogenesis</subject><subject>Pathology</subject><subject>Patients</subject><subject>Regression analysis</subject><subject>Sexual disorders</subject><subject>Urological surgery</subject><subject>Variables</subject><subject>Womens health</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdkd1rFDEUxYMottS--SwBXyo4NTfJJJmnItv1AxYsovgYMpm725SdZE1mxP73zbq1VF_yQX7nck4OIS-BnWvddu_8nHEu563iij8hxxyUaQwY-fTR-YiclnLDGAOmOdPsOTkSRnEBXB4TvExY6FVOm-zGEQe6wO2WXqKbrinQVdi4ONCzq6FZwRu6_L3LWEpIsSpwCH6iX7FayBg90hDpjzRiXUMVL-NQL1MOaXQXL8iztdsWPL3fT8j3D8tvi0_N6svHz4v3q8YLxqaGY-_XyJVjnint277rpJSdBujA8EFoA144JZUUAtYKGe-rUPYIOPC2leKEXBzm7ua-hvEYp-y2dpfD6PKtTS7Yf19iuLab9MsCMNBC7Sec3U_I6eeMZbJjKL7-iYuY5mIFE51hsjWioq__Q2_SnGPNV6nq2miu9tTbA-VzKiXj-sENMLvv0B46tH86rPirxwke4L-NiTsNS5bQ</recordid><startdate>20240316</startdate><enddate>20240316</enddate><creator>Goksever Celik, Hale</creator><creator>Celik, Engin</creator><creator>Uhri, Mehmet</creator><creator>Bastu, Ercan</creator><creator>Gungor, Mete</creator><creator>Buyru, Faruk</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240316</creationdate><title>Does Programmed Cell Death 1 Ligand (Pd-L1) Expression Predict Recurrence in Women With Endometrioma?</title><author>Goksever Celik, Hale ; Celik, Engin ; Uhri, Mehmet ; Bastu, Ercan ; Gungor, Mete ; Buyru, Faruk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-2ebcfe26a0c067c5b9944497119182d3781c3a6464331f6e02bc304be1ed25543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antigens</topic><topic>Cancer</topic><topic>Cell death</topic><topic>Chi-square test</topic><topic>Cohort analysis</topic><topic>Comorbidity</topic><topic>Cysts</topic><topic>Endometriosis</topic><topic>Hysterectomy</topic><topic>Independent sample</topic><topic>Infertility</topic><topic>Laparoscopy</topic><topic>Laparotomy</topic><topic>Ligands</topic><topic>Menstruation</topic><topic>Obstetrics/Gynecology</topic><topic>Ovaries</topic><topic>Parity</topic><topic>Pathogenesis</topic><topic>Pathology</topic><topic>Patients</topic><topic>Regression analysis</topic><topic>Sexual disorders</topic><topic>Urological surgery</topic><topic>Variables</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goksever Celik, Hale</creatorcontrib><creatorcontrib>Celik, Engin</creatorcontrib><creatorcontrib>Uhri, Mehmet</creatorcontrib><creatorcontrib>Bastu, Ercan</creatorcontrib><creatorcontrib>Gungor, Mete</creatorcontrib><creatorcontrib>Buyru, Faruk</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goksever Celik, Hale</au><au>Celik, Engin</au><au>Uhri, Mehmet</au><au>Bastu, Ercan</au><au>Gungor, Mete</au><au>Buyru, Faruk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does Programmed Cell Death 1 Ligand (Pd-L1) Expression Predict Recurrence in Women With Endometrioma?</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2024-03-16</date><risdate>2024</risdate><volume>16</volume><issue>3</issue><spage>e56262</spage><epage>e56262</epage><pages>e56262-e56262</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>The study aimed to evaluate whether there is a difference in the expression of programmed cell death 1 ligand (PD-L1) in the cell lining of endometrioma between cases with and without recurrent disease. Additionally, we sought to assess the effect of cyst size and serum CA125 level on the expression of PD-L1 staining. The pathological specimens were immunohistochemically stained for PD-L1 in women who underwent surgery for endometrioma. All patients were evaluated to confirm if their endometriomas had recurred or not. A total of 36 patients who underwent surgery for endometrioma were included. The study population was divided into two groups according to their recurrence status. The study group (having recurrence) (n=12) and the control group (having no recurrence) (n=24) were compared regarding their demographic and clinical characteristics and PD-L1 staining. PD-L1 staining and the intensity of PD-L1 staining did not differ between the patients with and without recurrence. No variable, including parity, cyst size, serum CA125 level, and PD-L1 staining, was found to be significant in determining recurrence. No significant difference was found between the groups with and without PD-L1 staining in terms of cyst size and serum CA125 level. Although we have shown that PD-L1 expression could not be used for the prediction of recurrence, further studies are needed to assess this issue and to guide the development of new immunotherapeutic agents on this basis.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>38623124</pmid><doi>10.7759/cureus.56262</doi><oa>free_for_read</oa></addata></record> |
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subjects | Antigens Cancer Cell death Chi-square test Cohort analysis Comorbidity Cysts Endometriosis Hysterectomy Independent sample Infertility Laparoscopy Laparotomy Ligands Menstruation Obstetrics/Gynecology Ovaries Parity Pathogenesis Pathology Patients Regression analysis Sexual disorders Urological surgery Variables Womens health |
title | Does Programmed Cell Death 1 Ligand (Pd-L1) Expression Predict Recurrence in Women With Endometrioma? |
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