Susceptibility of optic nerve head in children with posture-related elevation of intraocular pressure

Background/Aims This work aimed to investigate changes in optic nerve head (ONH) morphometry based on Bruch membrane opening in children with extensive nocturnal intraocular pressure (IOP) elevations. Methods The course of Bruch membrane opening-based optic nerve head (ONH) morphometry was analysed...

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Bibliographic Details
Published in:International ophthalmology 2024-04, Vol.44 (1), p.182-182, Article 182
Main Authors: Lüke, Jan Niklas, Gietzelt, Caroline, Enders, Philip, Dietlein, Johanna, Lappa, Alexandra, Lüke, Vincent, Widder, Randolf Alexander, Dietlein, Thomas S.
Format: Article
Language:English
Subjects:
Child
Children
Eye Diseases
Head (fluid mechanics)
Humans
Intraocular Pressure
Medicine
Medicine & Public Health
Membranes
Morphometry
Nerves
Ophthalmology
Optic Disk
Optic nerve
Original Paper
Position measurement
Posture
Retina
Supine position
Thickness
Tonometry, Ocular
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Summary:Background/Aims This work aimed to investigate changes in optic nerve head (ONH) morphometry based on Bruch membrane opening in children with extensive nocturnal intraocular pressure (IOP) elevations. Methods The course of Bruch membrane opening-based optic nerve head (ONH) morphometry was analysed in thirty-two patients younger than 18 years with evaluable SD-OCT examinations of the ONH and nocturnal posture-dependent IOP elevation above 25 mmHg. Longitudinal changes in neuroretinal rim tissue, as measured by Bruch Membrane opening minimum rim width (BMO-MRW) and peripapillary retinal nerve fiber layer (RNFL) thickness, were assessed. Results One year after the 24 h IOP measurement, global BMO-MRW (− 1.61 ± 16.8 µm, n.s.; p  = 0.611) and RNFL (+ 0.64 ± 3.17 µm; n.s.; p  = 0.292) measurements were not significantly different from the baseline. No significant BMO-MRW reduction (− 3.91 ± 24.3 µm; n.s. p  = 0.458) or deviation in RNFL thickness (+ 1.10 ± 3.52 µm) was observed at the four-year follow-up. Absolute IOP values measured in the supine position did not correlate with changes in global BMO-MRW or RNFL thickness. Conclusion Posture-dependent IOP elevations do not seem to influence retinal nerve fibre layer thickness or Bruch membrane opening-based morphometric data in childhood.
ISSN:1573-2630
0165-5701
1573-2630
DOI:10.1007/s10792-024-03109-6