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Lauren classification identifies distinct prognostic value and functional status of intratumoral CD8+ T cells in gastric cancer
With dichotomous etiology and pathogenesis, intestinal type and diffuse type gastric cancers vary in their clinical and molecular features to the point of representing distinct entities. However, the differences of tumor-infiltrating immune cells within the two types of gastric cancer have not been...
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| Published in: | Cancer Immunology, Immunotherapy Immunotherapy, 2020-07, Vol.69 (7), p.1327-1336 |
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| cites | cdi_FETCH-LOGICAL-c431t-2a69089e56aad11a3ac3656db6d92984dad78820daba56718b70cf57a9780c013 |
| container_end_page | 1336 |
| container_issue | 7 |
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| container_title | Cancer Immunology, Immunotherapy |
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| creator | Li, Ruochen Zhang, Heng Cao, Yifan Liu, Xin Chen, Yifan Qi, Yangyang Wang, Jieti Yu, Kuan Lin, Chao Liu, Hao He, Hongyong Li, He Chen, Lingli Shen, Zhenbin Qin, Jing Zhang, Weijuan Sun, Yihong Xu, Jiejie |
| description | With dichotomous etiology and pathogenesis, intestinal type and diffuse type gastric cancers vary in their clinical and molecular features to the point of representing distinct entities. However, the differences of tumor-infiltrating immune cells within the two types of gastric cancer have not been well researched. This study was aimed to evaluate the functional impact of Lauren classification on immune contexture in gastric cancer patients. Tumor tissues of gastric cancer patients from Zhongshan Hospital and gastric cancer data from The Cancer Genome Atlas (TCGA) cohort were analyzed. By immunohistochemistry and flow cytometry, we found that intratumoral CD8
+
T cells were more abundant but less functional in diffuse type as compared with those in intestinal type tumor tissues. Survival analysis indicated that CD8
+
T cells yielded favorable prognosis only in intestinal type patients other than diffuse type cancer patients. Moreover, such diffuse type-associated CD8
+
T cell dysfunction was featured by elevated expression of immunosuppressive factors including interleukin-10 (IL-10), transforming growth factor-β1 (TGF-β1) and indoleamine 2,3-dioxygenase 1 (IDO1). In summary, we found that the density, prognostic significance and functional status of intratumoral CD8
+
T cells varied with Lauren subtypes in gastric cancer. These results further indicated Lauren classification might be a potential therapeutic marker, and should be considered in therapeutic decisions, especially immunotherapeutic eligibility. |
| doi_str_mv | 10.1007/s00262-020-02550-7 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11027708</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2414567825</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-2a69089e56aad11a3ac3656db6d92984dad78820daba56718b70cf57a9780c013</originalsourceid><addsrcrecordid>eNp9UU2LFDEQDaK44-gf8CABL4K0VtIfSZ9Exk8Y8LKeQ02SHrP0JGOSXvDkX7fGWdePg4eQqnqvXqryGHss4IUAUC8LgBxkAxLo9D006g5bia6lku7FXbaCtqMiQHfBHpRyRYGEcbzPLlopT4lYse9bXLKP3M5YSpiCxRpS5MH5WCn1hbtQaoi28mNO-5gosfwa58VzjI5PC0HUgTMvFetSeJp4iDVTfEiZyps3-jm_5NbPcyGE77HUTBoWo_X5Ibs34Vz8o5t7zT6_e3u5-dBsP73_uHm9bWzXitpIHEbQo-8HRCcEtmjboR_cbnCjHHXn0CmtJTjcYT8ooXcK7NQrHJUGC6Jds1dn3eOyO3hn_WnE2RxzOGD-ZhIG8zcSwxezT9dGCJBKgSaFZzcKOX1dfKnmEMppK4w-LcXIVgvdaSAD1uzpP9SrtGT6I2J1oqMBteyJJc8sm1Mp2U-30wgwJ4PN2WBDBpufBhtFTU_-3OO25ZejRGjPhEJQ3Pv8--3_yP4Abeiy5Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2414567825</pqid></control><display><type>article</type><title>Lauren classification identifies distinct prognostic value and functional status of intratumoral CD8+ T cells in gastric cancer</title><source>PubMed</source><source>Springer Link</source><creator>Li, Ruochen ; Zhang, Heng ; Cao, Yifan ; Liu, Xin ; Chen, Yifan ; Qi, Yangyang ; Wang, Jieti ; Yu, Kuan ; Lin, Chao ; Liu, Hao ; He, Hongyong ; Li, He ; Chen, Lingli ; Shen, Zhenbin ; Qin, Jing ; Zhang, Weijuan ; Sun, Yihong ; Xu, Jiejie</creator><creatorcontrib>Li, Ruochen ; Zhang, Heng ; Cao, Yifan ; Liu, Xin ; Chen, Yifan ; Qi, Yangyang ; Wang, Jieti ; Yu, Kuan ; Lin, Chao ; Liu, Hao ; He, Hongyong ; Li, He ; Chen, Lingli ; Shen, Zhenbin ; Qin, Jing ; Zhang, Weijuan ; Sun, Yihong ; Xu, Jiejie</creatorcontrib><description>With dichotomous etiology and pathogenesis, intestinal type and diffuse type gastric cancers vary in their clinical and molecular features to the point of representing distinct entities. However, the differences of tumor-infiltrating immune cells within the two types of gastric cancer have not been well researched. This study was aimed to evaluate the functional impact of Lauren classification on immune contexture in gastric cancer patients. Tumor tissues of gastric cancer patients from Zhongshan Hospital and gastric cancer data from The Cancer Genome Atlas (TCGA) cohort were analyzed. By immunohistochemistry and flow cytometry, we found that intratumoral CD8
+
T cells were more abundant but less functional in diffuse type as compared with those in intestinal type tumor tissues. Survival analysis indicated that CD8
+
T cells yielded favorable prognosis only in intestinal type patients other than diffuse type cancer patients. Moreover, such diffuse type-associated CD8
+
T cell dysfunction was featured by elevated expression of immunosuppressive factors including interleukin-10 (IL-10), transforming growth factor-β1 (TGF-β1) and indoleamine 2,3-dioxygenase 1 (IDO1). In summary, we found that the density, prognostic significance and functional status of intratumoral CD8
+
T cells varied with Lauren subtypes in gastric cancer. These results further indicated Lauren classification might be a potential therapeutic marker, and should be considered in therapeutic decisions, especially immunotherapeutic eligibility.</description><identifier>ISSN: 0340-7004</identifier><identifier>EISSN: 1432-0851</identifier><identifier>DOI: 10.1007/s00262-020-02550-7</identifier><identifier>PMID: 32200421</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adenocarcinoma - classification ; Adenocarcinoma - immunology ; Adenocarcinoma - pathology ; Biomarkers, Tumor - analysis ; Cancer Research ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; Etiology ; Flow cytometry ; Follow-Up Studies ; Gastric cancer ; Genomes ; Humans ; Immunohistochemistry ; Immunology ; Interleukin 10 ; Intestine ; Lymphocytes ; Lymphocytes T ; Medical prognosis ; Medicine ; Medicine & Public Health ; Oncology ; Original ; Original Article ; Patients ; Prognosis ; Stomach Neoplasms - classification ; Stomach Neoplasms - immunology ; Stomach Neoplasms - pathology ; Survival analysis ; Transforming growth factor-b1 ; Tryptophan 2,3-dioxygenase ; Tumor-infiltrating lymphocytes</subject><ispartof>Cancer Immunology, Immunotherapy, 2020-07, Vol.69 (7), p.1327-1336</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-2a69089e56aad11a3ac3656db6d92984dad78820daba56718b70cf57a9780c013</citedby><cites>FETCH-LOGICAL-c431t-2a69089e56aad11a3ac3656db6d92984dad78820daba56718b70cf57a9780c013</cites><orcidid>0000-0001-7431-9063</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11027708/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11027708/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32200421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Ruochen</creatorcontrib><creatorcontrib>Zhang, Heng</creatorcontrib><creatorcontrib>Cao, Yifan</creatorcontrib><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Chen, Yifan</creatorcontrib><creatorcontrib>Qi, Yangyang</creatorcontrib><creatorcontrib>Wang, Jieti</creatorcontrib><creatorcontrib>Yu, Kuan</creatorcontrib><creatorcontrib>Lin, Chao</creatorcontrib><creatorcontrib>Liu, Hao</creatorcontrib><creatorcontrib>He, Hongyong</creatorcontrib><creatorcontrib>Li, He</creatorcontrib><creatorcontrib>Chen, Lingli</creatorcontrib><creatorcontrib>Shen, Zhenbin</creatorcontrib><creatorcontrib>Qin, Jing</creatorcontrib><creatorcontrib>Zhang, Weijuan</creatorcontrib><creatorcontrib>Sun, Yihong</creatorcontrib><creatorcontrib>Xu, Jiejie</creatorcontrib><title>Lauren classification identifies distinct prognostic value and functional status of intratumoral CD8+ T cells in gastric cancer</title><title>Cancer Immunology, Immunotherapy</title><addtitle>Cancer Immunol Immunother</addtitle><addtitle>Cancer Immunol Immunother</addtitle><description>With dichotomous etiology and pathogenesis, intestinal type and diffuse type gastric cancers vary in their clinical and molecular features to the point of representing distinct entities. However, the differences of tumor-infiltrating immune cells within the two types of gastric cancer have not been well researched. This study was aimed to evaluate the functional impact of Lauren classification on immune contexture in gastric cancer patients. Tumor tissues of gastric cancer patients from Zhongshan Hospital and gastric cancer data from The Cancer Genome Atlas (TCGA) cohort were analyzed. By immunohistochemistry and flow cytometry, we found that intratumoral CD8
+
T cells were more abundant but less functional in diffuse type as compared with those in intestinal type tumor tissues. Survival analysis indicated that CD8
+
T cells yielded favorable prognosis only in intestinal type patients other than diffuse type cancer patients. Moreover, such diffuse type-associated CD8
+
T cell dysfunction was featured by elevated expression of immunosuppressive factors including interleukin-10 (IL-10), transforming growth factor-β1 (TGF-β1) and indoleamine 2,3-dioxygenase 1 (IDO1). In summary, we found that the density, prognostic significance and functional status of intratumoral CD8
+
T cells varied with Lauren subtypes in gastric cancer. These results further indicated Lauren classification might be a potential therapeutic marker, and should be considered in therapeutic decisions, especially immunotherapeutic eligibility.</description><subject>Adenocarcinoma - classification</subject><subject>Adenocarcinoma - immunology</subject><subject>Adenocarcinoma - pathology</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Cancer Research</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Etiology</subject><subject>Flow cytometry</subject><subject>Follow-Up Studies</subject><subject>Gastric cancer</subject><subject>Genomes</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunology</subject><subject>Interleukin 10</subject><subject>Intestine</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original</subject><subject>Original Article</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Stomach Neoplasms - classification</subject><subject>Stomach Neoplasms - immunology</subject><subject>Stomach Neoplasms - pathology</subject><subject>Survival analysis</subject><subject>Transforming growth factor-b1</subject><subject>Tryptophan 2,3-dioxygenase</subject><subject>Tumor-infiltrating lymphocytes</subject><issn>0340-7004</issn><issn>1432-0851</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9UU2LFDEQDaK44-gf8CABL4K0VtIfSZ9Exk8Y8LKeQ02SHrP0JGOSXvDkX7fGWdePg4eQqnqvXqryGHss4IUAUC8LgBxkAxLo9D006g5bia6lku7FXbaCtqMiQHfBHpRyRYGEcbzPLlopT4lYse9bXLKP3M5YSpiCxRpS5MH5WCn1hbtQaoi28mNO-5gosfwa58VzjI5PC0HUgTMvFetSeJp4iDVTfEiZyps3-jm_5NbPcyGE77HUTBoWo_X5Ibs34Vz8o5t7zT6_e3u5-dBsP73_uHm9bWzXitpIHEbQo-8HRCcEtmjboR_cbnCjHHXn0CmtJTjcYT8ooXcK7NQrHJUGC6Jds1dn3eOyO3hn_WnE2RxzOGD-ZhIG8zcSwxezT9dGCJBKgSaFZzcKOX1dfKnmEMppK4w-LcXIVgvdaSAD1uzpP9SrtGT6I2J1oqMBteyJJc8sm1Mp2U-30wgwJ4PN2WBDBpufBhtFTU_-3OO25ZejRGjPhEJQ3Pv8--3_yP4Abeiy5Q</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Li, Ruochen</creator><creator>Zhang, Heng</creator><creator>Cao, Yifan</creator><creator>Liu, Xin</creator><creator>Chen, Yifan</creator><creator>Qi, Yangyang</creator><creator>Wang, Jieti</creator><creator>Yu, Kuan</creator><creator>Lin, Chao</creator><creator>Liu, Hao</creator><creator>He, Hongyong</creator><creator>Li, He</creator><creator>Chen, Lingli</creator><creator>Shen, Zhenbin</creator><creator>Qin, Jing</creator><creator>Zhang, Weijuan</creator><creator>Sun, Yihong</creator><creator>Xu, Jiejie</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7431-9063</orcidid></search><sort><creationdate>20200701</creationdate><title>Lauren classification identifies distinct prognostic value and functional status of intratumoral CD8+ T cells in gastric cancer</title><author>Li, Ruochen ; Zhang, Heng ; Cao, Yifan ; Liu, Xin ; Chen, Yifan ; Qi, Yangyang ; Wang, Jieti ; Yu, Kuan ; Lin, Chao ; Liu, Hao ; He, Hongyong ; Li, He ; Chen, Lingli ; Shen, Zhenbin ; Qin, Jing ; Zhang, Weijuan ; Sun, Yihong ; Xu, Jiejie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-2a69089e56aad11a3ac3656db6d92984dad78820daba56718b70cf57a9780c013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adenocarcinoma - classification</topic><topic>Adenocarcinoma - immunology</topic><topic>Adenocarcinoma - pathology</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Cancer Research</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Etiology</topic><topic>Flow cytometry</topic><topic>Follow-Up Studies</topic><topic>Gastric cancer</topic><topic>Genomes</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Immunology</topic><topic>Interleukin 10</topic><topic>Intestine</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original</topic><topic>Original Article</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Stomach Neoplasms - classification</topic><topic>Stomach Neoplasms - immunology</topic><topic>Stomach Neoplasms - pathology</topic><topic>Survival analysis</topic><topic>Transforming growth factor-b1</topic><topic>Tryptophan 2,3-dioxygenase</topic><topic>Tumor-infiltrating lymphocytes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Ruochen</creatorcontrib><creatorcontrib>Zhang, Heng</creatorcontrib><creatorcontrib>Cao, Yifan</creatorcontrib><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Chen, Yifan</creatorcontrib><creatorcontrib>Qi, Yangyang</creatorcontrib><creatorcontrib>Wang, Jieti</creatorcontrib><creatorcontrib>Yu, Kuan</creatorcontrib><creatorcontrib>Lin, Chao</creatorcontrib><creatorcontrib>Liu, Hao</creatorcontrib><creatorcontrib>He, Hongyong</creatorcontrib><creatorcontrib>Li, He</creatorcontrib><creatorcontrib>Chen, Lingli</creatorcontrib><creatorcontrib>Shen, Zhenbin</creatorcontrib><creatorcontrib>Qin, Jing</creatorcontrib><creatorcontrib>Zhang, Weijuan</creatorcontrib><creatorcontrib>Sun, Yihong</creatorcontrib><creatorcontrib>Xu, Jiejie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer Immunology, Immunotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Ruochen</au><au>Zhang, Heng</au><au>Cao, Yifan</au><au>Liu, Xin</au><au>Chen, Yifan</au><au>Qi, Yangyang</au><au>Wang, Jieti</au><au>Yu, Kuan</au><au>Lin, Chao</au><au>Liu, Hao</au><au>He, Hongyong</au><au>Li, He</au><au>Chen, Lingli</au><au>Shen, Zhenbin</au><au>Qin, Jing</au><au>Zhang, Weijuan</au><au>Sun, Yihong</au><au>Xu, Jiejie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lauren classification identifies distinct prognostic value and functional status of intratumoral CD8+ T cells in gastric cancer</atitle><jtitle>Cancer Immunology, Immunotherapy</jtitle><stitle>Cancer Immunol Immunother</stitle><addtitle>Cancer Immunol Immunother</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>69</volume><issue>7</issue><spage>1327</spage><epage>1336</epage><pages>1327-1336</pages><issn>0340-7004</issn><eissn>1432-0851</eissn><abstract>With dichotomous etiology and pathogenesis, intestinal type and diffuse type gastric cancers vary in their clinical and molecular features to the point of representing distinct entities. However, the differences of tumor-infiltrating immune cells within the two types of gastric cancer have not been well researched. This study was aimed to evaluate the functional impact of Lauren classification on immune contexture in gastric cancer patients. Tumor tissues of gastric cancer patients from Zhongshan Hospital and gastric cancer data from The Cancer Genome Atlas (TCGA) cohort were analyzed. By immunohistochemistry and flow cytometry, we found that intratumoral CD8
+
T cells were more abundant but less functional in diffuse type as compared with those in intestinal type tumor tissues. Survival analysis indicated that CD8
+
T cells yielded favorable prognosis only in intestinal type patients other than diffuse type cancer patients. Moreover, such diffuse type-associated CD8
+
T cell dysfunction was featured by elevated expression of immunosuppressive factors including interleukin-10 (IL-10), transforming growth factor-β1 (TGF-β1) and indoleamine 2,3-dioxygenase 1 (IDO1). In summary, we found that the density, prognostic significance and functional status of intratumoral CD8
+
T cells varied with Lauren subtypes in gastric cancer. These results further indicated Lauren classification might be a potential therapeutic marker, and should be considered in therapeutic decisions, especially immunotherapeutic eligibility.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32200421</pmid><doi>10.1007/s00262-020-02550-7</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-7431-9063</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer Immunology, Immunotherapy, 2020-07, Vol.69 (7), p.1327-1336 |
| issn | 0340-7004 1432-0851 |
| language | eng |
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| source | PubMed; Springer Link |
| subjects | Adenocarcinoma - classification Adenocarcinoma - immunology Adenocarcinoma - pathology Biomarkers, Tumor - analysis Cancer Research CD8 antigen CD8-Positive T-Lymphocytes - immunology Etiology Flow cytometry Follow-Up Studies Gastric cancer Genomes Humans Immunohistochemistry Immunology Interleukin 10 Intestine Lymphocytes Lymphocytes T Medical prognosis Medicine Medicine & Public Health Oncology Original Original Article Patients Prognosis Stomach Neoplasms - classification Stomach Neoplasms - immunology Stomach Neoplasms - pathology Survival analysis Transforming growth factor-b1 Tryptophan 2,3-dioxygenase Tumor-infiltrating lymphocytes |
| title | Lauren classification identifies distinct prognostic value and functional status of intratumoral CD8+ T cells in gastric cancer |
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