High prevalence of antibodies reacting to mimotopes of Simian virus 40 large T antigen, the oncoprotein, in serum samples of patients affected by non-Hodgkin lymphoma

A new immunological investigation was carried out to study the association between non-Hodgkin lymphoma and Simian virus 40 (SV40). To this end, a new indirect ELISA was employed with two mimotopes from SV40 large T antigen (Tag), the viral oncoprotein, to analyse for specific reactions to antibodie...

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Bibliographic Details
Published in:Cancer Immunology, Immunotherapy Immunotherapy, 2017-09, Vol.66 (9), p.1189-1198
Main Authors: Mazzoni, Elisa, Pietrobon, Silvia, Bilancia, Miriam, Vinante, Fabrizio, Rigo, Antonella, Ferrarini, Isacco, D’Agostino, Antonio, Casali, Maria Vittoria, Martini, Fernanda, Tognon, Mauro
Format: Article
Language:English
Subjects:
Adult
Animals
Antibodies
Antibodies, Viral - immunology
Antigen T (large)
Antigens
Antigens, Viral, Tumor - immunology
Breast cancer
Breast carcinoma
Cancer Research
Enzyme-linked immunosorbent assay
Female
Humans
Immunoglobulin G
Immunoglobulins
Immunology
Lymphoma
Lymphoma, Non-Hodgkin - immunology
Lymphoma, Non-Hodgkin - pathology
Medicine
Medicine & Public Health
Mice
Mice, Transgenic
Middle Aged
Oncogene Proteins - metabolism
Oncology
Oncoproteins
Original
Original Article
Prevalence
Simian virus 40 - immunology
Statistical analysis
Tumors
Viruses
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Summary:A new immunological investigation was carried out to study the association between non-Hodgkin lymphoma and Simian virus 40 (SV40). To this end, a new indirect ELISA was employed with two mimotopes from SV40 large T antigen (Tag), the viral oncoprotein, to analyse for specific reactions to antibodies in sera from non-Hodgkin lymphoma patients and controls, represented by healthy subjects (HS) and breast carcinoma (BC) patients. This study allowed us to assay a new sera collection from non-Hodgkin lymphoma patients (NHL, n  = 254). To verify the association between NHL and SV40 Tag, two totally independent cohorts were analysed: NHL1 n  = 150 and NHL2 n  = 104. The epidemiological survey included sera from HS1, n  = 150; HS2, n  = 104 and BC, n  = 78. This new indirect ELISA revealed that antibodies against SV40 Tag mimotopes are detectable in NHL1 and NHL2 sera with a prevalence of 37 and 36%, respectively. The prevalence of SV40-antibodies detected in both NHL1 and NHL2 cohorts differs statistically from controls, at 19% for HS1 ( p  
ISSN:0340-7004
1432-0851
DOI:10.1007/s00262-017-2008-9