Elevated level of peripheral CD8+CD28− T lymphocytes are an independent predictor of progression-free survival in patients with metastatic breast cancer during the course of chemotherapy

Purpose Suppression of cellular immunity resulting from tumorigenesis and/or therapy might promote cancer cells’ growth, progression and invasion. Here, we explored whether T lymphocyte subtypes from peripheral blood of metastatic breast cancer (MBC) female patients could be used as alternative surr...

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Bibliographic Details
Published in:Cancer Immunology, Immunotherapy Immunotherapy, 2013-06, Vol.62 (6), p.1123-1130
Main Authors: Song, Guohong, Wang, Xiaoli, Jia, Jun, Yuan, Yanhua, Wan, Fengling, Zhou, Xinna, Yang, Huabing, Ren, Jun, Gu, Jiezhun, Lyerly, Herbert Kim
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Breast Neoplasms - drug therapy
Breast Neoplasms - immunology
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Cancer Research
Case-Control Studies
CD28 Antigens - metabolism
CD8 Antigens - metabolism
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - metabolism
Cohort Studies
Cytokines - blood
Female
Humans
Immunology
Immunophenotyping
Lymphocyte Count
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Metastasis
Oncology
Original
Original Article
Prognosis
Risk Factors
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
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Summary:Purpose Suppression of cellular immunity resulting from tumorigenesis and/or therapy might promote cancer cells’ growth, progression and invasion. Here, we explored whether T lymphocyte subtypes from peripheral blood of metastatic breast cancer (MBC) female patients could be used as alternative surrogate markers for cancer progress. Additionally, plasma levels of interleukin (IL)-2, IL-4, IL-6, IL-10, IFN-γ, and transforming growth factor-β1 were quantitated from MBC and healthy volunteers. Experimental design This study included 89 female MBC patients during the post-salvage chemotherapy follow-up and 50 age- and sex-matched healthy volunteers as control. The percentages of T lymphocyte subpopulations from peripheral blood and plasma levels of cytokines were measured. Results Both CD8 + CD28 − and CD4 + CD25 + were elevated in MBC patients compared to the control cohort ( P  
ISSN:0340-7004
1432-0851
DOI:10.1007/s00262-013-1424-8