CD4⁺CD45RA⁺CXCR4⁺ lymphocytes are inversely associated with progression in stages I-III melanoma patients

The chemokine receptor CXCR4 was described as an independent predictor of poor prognosis in primary human melanoma. To investigate on a possible role of CXCR4 expression on peripheral blood lymphocytes (PBL) subsets, 195 patients with melanoma were evaluated for correlations between PBL subsets CXCR...

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Published in:Cancer Immunology, Immunotherapy Immunotherapy, 2010-04, Vol.59 (4), p.511-517
Main Authors: Napolitano, Maria, Ottaiano, Alessandro, Mauro, Francesca, Ieranò, Caterina, Satriano, Rocco, Pacelli, Roberto, Franco, Renato, De Angelis, Valentina, Castello, Giuseppe, Scala, Stefania
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antineoplastic agents
Biological and medical sciences
Cancer Research
CD4-Positive T-Lymphocytes - immunology
CXCR4
Dermatology
Disease Progression
Female
Flow Cytometry
Follow-Up Studies
Humans
Immunology
Immunotherapy
Leukocyte Common Antigens - metabolism
Male
Medical sciences
Medicine
Medicine & Public Health
melanoma
Melanoma - immunology
Melanoma - metabolism
Middle Aged
Neoplasm Staging
Oncology
Original
Original Article
Pharmacology. Drug treatments
Prognosis
Prospective Studies
Receptors, CXCR4 - metabolism
Skin Neoplasms - immunology
Skin Neoplasms - metabolism
Survival Rate
Tumors of the skin and soft tissue. Premalignant lesions
Young Adult
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Summary:The chemokine receptor CXCR4 was described as an independent predictor of poor prognosis in primary human melanoma. To investigate on a possible role of CXCR4 expression on peripheral blood lymphocytes (PBL) subsets, 195 patients with melanoma were evaluated for correlations between PBL subsets CXCR4 expressing and clinicopathological and prognostic features. One hundred ninety-five patients with stages I-III melanoma were enrolled in this study. Lymphocytes subsets were assayed by the direct fluorescence method for whole blood and staining with fluorochrome-conjugated monoclonal antibodies. Correlations between PBL subsets, baseline patient, and tumor features were studied by contingency tables and the χ² test. The Kaplan-Meier product limit method was applied to plot disease-free- and overall-survival curves. Univariate analysis was performed with the log-rank test. Cox proportional-hazards regression was used to analyze the effect of multiple risk factors on disease-free survival (DFS). Melanoma patients characterized by CD4⁺CD45RA⁺CXCR4⁺ higher than 25% of PBL showed a longer DFS. Conversely, CD4⁺CD45RA⁺CXCR4⁺
ISSN:0340-7004
1432-0851
DOI:10.1007/s00262-009-0766-8