Maturation of circulating dendritic cells and imbalance of T-cell subsets in patients with squamous cell carcinoma of the head and neck

Interactions between dendritic cells (DCs) and T cells play a pivotal role in the regulation and maintenance of immune responses. In cancer patients, various immunological abnormalities have been observed in these immune cells. Here, we investigated proportions and the phenotype of DCs and the cytok...

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Bibliographic Details
Published in:Cancer Immunology, Immunotherapy Immunotherapy, 2006-02, Vol.55 (2), p.151-159
Main Authors: SAKAKURA, Koichi, CHIKAMATSU, Kazuaki, TAKAHASHI, Katsumasa, WHITESIDE, Theresa L, FURUYA, Nobuhiko
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antineoplastic agents
Biological and medical sciences
Carcinoma, Squamous Cell - immunology
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Cell Differentiation - immunology
Cytokines - biosynthesis
Cytokines - immunology
Dendritic Cells - cytology
Dendritic Cells - immunology
Flow Cytometry - methods
Head and Neck Neoplasms - immunology
HLA-DR Antigens - analysis
HLA-DR Antigens - biosynthesis
Humans
Immunotherapy
Medical sciences
Middle Aged
Original
Pharmacology. Drug treatments
Th1 Cells - immunology
Th2 Cells - immunology
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Summary:Interactions between dendritic cells (DCs) and T cells play a pivotal role in the regulation and maintenance of immune responses. In cancer patients, various immunological abnormalities have been observed in these immune cells. Here, we investigated proportions and the phenotype of DCs and the cytokine profile of T-cell subsets in the peripheral blood of patients with squamous cell carcinoma of the head and neck (SCCHN), using multicolor flow cytometry. The percentage of myeloid (CD11c(+)), but not plasmacytoid (CD123(+)) DCs, was significantly lower (P
ISSN:0340-7004
1432-0851
1365-2567
DOI:10.1007/s00262-005-0697-y