Regulation of immunity and oncogenesis by the IRF transcription factor family

Nine interferon regulatory factors (IRFs) compose a family of transcription factors in mammals. Although this family was originally identified in the context of the type I interferon system, subsequent studies have revealed much broader functions performed by IRF members in host defense. In this rev...

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Bibliographic Details
Published in:Cancer Immunology, Immunotherapy Immunotherapy, 2010-04, Vol.59 (4), p.489-510
Main Authors: Savitsky, David, Tamura, Tomohiko, Yanai, Hideyuki, Taniguchi, Tadatsugu
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Biological and medical sciences
Cancer Research
Humans
Immune response
Immunity - physiology
Immunology
Immunotherapy
Interferon
Interferon Regulatory Factors - physiology
Medical sciences
Medicine
Medicine & Public Health
Neoplasms - metabolism
Oncology
Pharmacology. Drug treatments
Review
Transcription factors
Tumorigenesis
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Summary:Nine interferon regulatory factors (IRFs) compose a family of transcription factors in mammals. Although this family was originally identified in the context of the type I interferon system, subsequent studies have revealed much broader functions performed by IRF members in host defense. In this review, we provide an update on the current knowledge of their roles in immune responses, immune cell development, and regulation of oncogenesis.
ISSN:0340-7004
1432-0851
DOI:10.1007/s00262-009-0804-6