Effect of Zusanli Acupoint Injection with Anisodamine on Postoperative Recovery Quality of Patients Undergoing Bariatric Surgery

• Published in: Obesity surgery 2024-05, Vol.34 (5), p.1717-1725
• Main Authors: Cheng, Jianxin, Wang, Xiaohan, Wang, Rui, Sheng, Jingyi, Guo, Shanshan, Liu, Tianya, Wang, Zhiping
• Format: Article
• Language: English
• Subjects: Acupuncture Points; Bariatric Surgery; Gastrointestinal surgery; Humans; Laparoscopy; Medicine; Medicine & Public Health; Obesity, Morbid - surgery; Original Contributions; Pain; Pain, Postoperative - drug therapy; Pain, Postoperative - prevention & control; Postoperative Nausea and Vomiting; Solanaceous Alkaloids; Surgery
• ISSN: 0960-8923; 1708-0428
• DOI: 10.1007/s11695-024-07182-9

Purpose To evaluate the influence of anisodamine injection at the Zusanli (ST36) on early postoperative recovery quality in patients who have undergone laparoscopic sleeve gastrectomy. Materials and Methods 141 patients undergoing laparoscopic sleeve gastrectomy were randomly divided into the control group (group C), the normal saline group (group S) and the anisodamine group (group A). Acupuncture point injections were administered after induction of general anesthesia. The quality of recovery-40 questionnaire (QoR-40) scores were documented preoperatively (D0) and on the 1st (D1), 3rd (D3) and 7th (D7) days postoperatively. Additional metrics included: the numerical rating scale (NRS) for pain, postoperative nausea and vomiting (PONV), assessment and analgesic consumption 24-h post-extubation and the initial postoperative times for ambulation and anal exhaust. Substance P (SP), β-endorphin (β-EP), motilin (MTL) and gastrin (GAS) were quantified at 24-h post-surgery. Results Compared with group C, group A demonstrated an elevation in QoR-40 scores and physical comfort dimensions during D1-3, and an increased pain scores during D1-7; group S exhibited an augmentation in QoR-40 scores and pain scores on D1 ( p