Expression of IAP family proteins in colon cancers from patients with different age groups

Members of the inhibitor of apoptosis protein (IAP) family including survivin, are expressed in many tumors. However, age-related changes in their expression in cancer have not been clarified. Thus, we investigated the expression of mRNA-coding for IAP family proteins in colon cancer samples from yo...

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Bibliographic Details
Published in:Cancer Immunology, Immunotherapy Immunotherapy, 2004-09, Vol.53 (9), p.770-776
Main Authors: ENDO, T, ABE, S, SEIDLAR, H. B. K, NAGAOKA, S, TAKEMURA, T, UTSUYAMA, M, KITAGAWA, M, HIROKAWA, K
Format: Article
Language:English
Subjects:
Adenocarcinoma - diagnosis
Adenocarcinoma - genetics
Adenocarcinoma - metabolism
Adult
Age Distribution
Aged
Aged, 80 and over
Antineoplastic agents
Biological and medical sciences
Biomarkers, Tumor
Cell Differentiation
Colon - metabolism
Colon - pathology
Colonic Neoplasms - diagnosis
Colonic Neoplasms - genetics
Colonic Neoplasms - metabolism
Female
Gene Expression Regulation, Neoplastic
Humans
Immunoenzyme Techniques
Inhibitor of Apoptosis Proteins
Male
Medical sciences
Microtubule-Associated Proteins - genetics
Microtubule-Associated Proteins - metabolism
Middle Aged
Neoplasm Proteins
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - metabolism
Neuronal Apoptosis-Inhibitory Protein
Original
Pharmacology. Drug treatments
Prognosis
Proteins - genetics
Proteins - metabolism
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - metabolism
Survivin
Tumors
Ubiquitin-Protein Ligases
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Summary:Members of the inhibitor of apoptosis protein (IAP) family including survivin, are expressed in many tumors. However, age-related changes in their expression in cancer have not been clarified. Thus, we investigated the expression of mRNA-coding for IAP family proteins in colon cancer samples from young (70 years) patients by real-time quantitative RT-PCR. Samples were collected from cases with well-differentiated adenocarcinoma or moderately differentiated adenocarcinoma and their adjacent normal epithelial tissue. Well-differentiated adenocarcinoma tended to express higher levels of survivin than normal mucosa, and expression in moderately differentiated adenocarcinoma was significantly greater than in normal mucosa in samples from both groups of patients ( p
ISSN:0340-7004
1432-0851
DOI:10.1007/s00262-004-0534-8