Body composition in adults born preterm with very low birth weight

Background Studies on body composition in preterm very low birth weight (VLBW 0.3). Conclusion Compared with term-born controls, VLBW adults had similar body fat percentage but lower lean body mass, largely explained by their shorter height. This could contribute to lower insulin sensitivity and mus...

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Published in:Pediatric research 2024-04, Vol.95 (5), p.1316-1324
Main Authors: Jussinniemi, Laura, Kulmala, Maarit K., Aakvik, Kristina A. D., Benum, Silje D., Jørgensen, Anna P. M., Balasuriya, Chandima N. D., Stunes, Astrid K., Syversen, Unni, Indredavik, Marit S., Andersson, Sture, Hovi, Petteri, Evensen, Kari Anne I., Kajantie, Eero
Format: Article
Language:English
Subjects:
Adults
Birth weight
Body composition
Body fat
Body mass index
Clinical
Clinical Research Article
Insulin
Medicine
Medicine & Public Health
Pediatric Surgery
Pediatrics
Sensitivity analysis
Women
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Summary:Background Studies on body composition in preterm very low birth weight (VLBW 0.3). Conclusion Compared with term-born controls, VLBW adults had similar body fat percentage but lower lean body mass, largely explained by their shorter height. This could contribute to lower insulin sensitivity and muscular fitness previously found in VLBW survivors and predispose to functional limitations with increasing age. Impact In mid-adulthood, individuals born preterm with very low birth weight had similar body fat percentage but lower lean body mass than those born at term. This was largely explained by their shorter height. First study to report longitudinal assessments of body size and composition from young to mid-adulthood in very low birth weight adults. Lower lean body mass in very low birth weight adults could contribute to lower insulin sensitivity and muscular fitness and lead to earlier functional limitations with increasing age.
ISSN:0031-3998
1530-0447
DOI:10.1038/s41390-023-02896-5