Ability of recombinant interferon gamma in vitro to restore the defective polymorphonuclear-cell- but not lymphocyte-mediated cytotoxic activities in patients with myelodysplastic syndromes

In this study we analysed the in vitro effect of recombinant interferon gamma on cytotoxic activities mediated by both lymphoid and polymorphonuclear cells from 16 patients with myelodysplastic syndromes. Our results indicate the inability of interferon to restore the defective natural killer activi...

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Bibliographic Details
Published in:Cancer Immunology, Immunotherapy Immunotherapy, 1992-11, Vol.34 (6), p.414-418
Main Authors: De Sanctis, G, Bottari, V, Frezzolini, A, Ficcardi, M, De Rossi, G, Petti, M C, Mandelli, F, Fontana, L
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Animals
Antibody-Dependent Cell Cytotoxicity - drug effects
Antibody-Dependent Cell Cytotoxicity - immunology
Chickens
Cytotoxicity, Immunologic - drug effects
Female
Humans
Immunity, Cellular - drug effects
Interferon-gamma - pharmacology
Killer Cells, Natural - drug effects
Killer Cells, Natural - immunology
Lymphocytes - drug effects
Lymphocytes - immunology
Male
Middle Aged
Myelodysplastic Syndromes - drug therapy
Myelodysplastic Syndromes - immunology
Neutrophils - drug effects
Neutrophils - immunology
Original
Phytohemagglutinins
Recombinant Proteins
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Summary:In this study we analysed the in vitro effect of recombinant interferon gamma on cytotoxic activities mediated by both lymphoid and polymorphonuclear cells from 16 patients with myelodysplastic syndromes. Our results indicate the inability of interferon to restore the defective natural killer activity, natural killer cells and lectin-induced cytotoxicity. On the contrary we detected a boosting effect on the depressed polymorphonuclear cell cytotoxic activities. In our view, the ability of interferon to potentiate polymorphonuclear cell lytic efficiency could support an alternative defensive pathway against either neoplastic or infectious agents.
ISSN:0340-7004
1432-0851
DOI:10.1007/BF01741753