Epidermal growth factor receptor expression in human gliomas

The expression of epidermal growth factor receptor (EGFR) was determined in cryosections of 42 human gliomas using biotinylated epidermal growth factor (B-EGF) and two monoclonal antibodies (mAb) against EGFR. All gliomas were found to express EGFR when examined with B-EGF, whereas 33 expressed EGFR...

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Bibliographic Details
Published in:Cancer Immunology Immunotherapy 1991-01, Vol.33 (1), p.61-64
Main Authors: TORP, S. H, HELSETH, E, DALEN, A, UNSGAARD, G
Format: Article
Language:English
Subjects:
Adult
Aged
Antibodies, Monoclonal
Biological and medical sciences
Brain Chemistry
Brain Neoplasms - chemistry
Child
Epidermal Growth Factor - metabolism
ErbB Receptors - analysis
Female
Fluorescence
Glioma - chemistry
Histocytochemistry
Humans
Male
Medical sciences
Middle Aged
Neurons - chemistry
Original
Tumors
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Summary:The expression of epidermal growth factor receptor (EGFR) was determined in cryosections of 42 human gliomas using biotinylated epidermal growth factor (B-EGF) and two monoclonal antibodies (mAb) against EGFR. All gliomas were found to express EGFR when examined with B-EGF, whereas 33 expressed EGFR when examined with the two mAbs. The highly malignant gliomas (glioblastomas and anaplastic astrocytomas) had a more heterogeneous staining strongly with B-EGF than did the low-grade gliomas (astrocytomas, oligodendrogliomas, mixed gliomas, and ependymomas). This indicates that high-grade gliomas contain more tumour cells rich in EGFR than do the low-grade gliomas. Reactive astrocytes, ependymal cells, and many types of nerve cells (cerebral cortical pyramidal cells, pyramidal and granular hippocampal cells, Purkinje cells, cerebellar granular cells and neurons in the molecular layer of the cerebellum) expressed EGFR, whereas small neurons and normal glial cells were not found to express EGFR.
ISSN:0340-7004
1432-0851
DOI:10.1007/BF01742530