In vitro expression of secondary antitumor immunity by in vivo tumor-sensitized T cells: inhibition by tumor-induced suppressor T cells

In vitro cultivation of memory immune cells from P815- or P388-immune mice with corresponding irradiated tumor cells induced generation of cytolytic T cells (CTL). The induction of CTL generation, as well as the cytolytic activity itself, was tumor-specific. The in vitro generation of CTL from P815-...

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Bibliographic Details
Published in:Cancer Immunology Immunotherapy 1987-09, Vol.25 (2), p.69-74
Main Authors: ZEHRA KAYMAKCALAN, SPITALNY, G. L, BURSUKER, I
Format: Article
Language:English
Subjects:
Biological and medical sciences
Host-tumor relations. Immunology. Biological markers
Medical sciences
Original
Tumors
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Summary:In vitro cultivation of memory immune cells from P815- or P388-immune mice with corresponding irradiated tumor cells induced generation of cytolytic T cells (CTL). The induction of CTL generation, as well as the cytolytic activity itself, was tumor-specific. The in vitro generation of CTL from P815- or P388-immune cells was suppressed by spleen cells from mice bearing corresponding progressive tumors (tumor size 15 mm). The tumor-induced suppressor cells suppressed the in vitro generation of CTL, but did not affect their cytolytic function. The suppression was tumor-specific and was mediated by Ly1 + 2 − L3T4 + T cells. Treatment of suppressor cell donors with cyclophosphamide or sublethal γ-radiation completely abolished the ability of their spleen cells to inhibit the in vitro CTL generation.
ISSN:0340-7004
1432-0851
DOI:10.1007/BF00199943