Reaction of the leukocytes of melanoma patients and control donors, including pregnant women, with melanoma- and fetus-derived materials

Using a one-stage capillary leukocyte migration inhibition assay, we examined peripheral blood leukocytes from 97 patients with malignant melanoma, 194 pregnant women, and 123 non-pregnant donors for their reactivity with materials from fetal and melanomatous tissues. As in previous studies, we foun...

Full description

Saved in:
Bibliographic Details
Published in:Cancer Immunology Immunotherapy 1982-12, Vol.14 (2), p.78-81
Main Authors: Cochran, A J, Todd, G, Hart, D M, Morrison, L J, MacKie, R M
Format: Article
Language:English
Subjects:
Cell Migration Inhibition
Female
Fetus - immunology
Humans
Leukocytes - immunology
Melanoma - immunology
Original
Placenta - immunology
Pregnancy - immunology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Using a one-stage capillary leukocyte migration inhibition assay, we examined peripheral blood leukocytes from 97 patients with malignant melanoma, 194 pregnant women, and 123 non-pregnant donors for their reactivity with materials from fetal and melanomatous tissues. As in previous studies, we found melanoma extracts selectively to inhibit melanoma patients' leukocytes. First-trimester fetal extracts also selectively inhibited melanoma patients' leukocytes, suggesting their cross-reactivity with melanoma-derived antigens. We could not localize the source of the inhibitory materials within the fetuses. We found no evidence that pregnant women were selectively immunized to fetal or melanoma extracts, regardless of their parity or the stage of their pregnancy.
ISSN:0340-7004
1432-0851
DOI:10.1007/BF00200171