A Prospective, Observational Study of the Effect of a High-Calorie, High-Protein Oral Nutritional Supplement with HMB in an Old and Malnourished or at-Risk-of-Malnutrition Population with Hip Fractures: A FracNut Study

• Published in: Nutrients 2024-04, Vol.16 (8), p.1223
• Main Authors: Pareja Sierra, Teresa, Hünicken Torrez, Flavia Lorena, Pablos Hernández, María Carmen, López Velasco, Rosario, Ortés Gómez, Raquel, Cervera Díaz, María Del Carmen, Hormigo Sánchez, Ana Isabel, Perdomo Ramírez, Beatriz, Mora Fernández, Jesús, Jiménez Mola, Sonia, Rodriguez Piñera, María Amparo, Condorhuaman Alvarado, Patricia Ysabel, Sanchez Juan, Carlos, Ramos Clemente, Juan Ignacio, Veses Martín, Silvia, Rodríguez Manzano, Ingrid, González-Colaço Harmand, Magali, Camprubí Robles, María, Martín Aguilar, Andrea, Saez Lopez, Pilar
• Format: Article
• Language: English
• Subjects: Activities of daily living; Administration, Oral; Aged; Aged, 80 and over; Bones; Density; Diet, High-Protein; Dietary Proteins - administration & dosage; Dietary Supplements; Energy Intake; Female; Fractures; Frailty; Health care industry; Hip Fractures; Hip joint; Humans; Male; Malnutrition; Malnutrition - etiology; Mortality; Nutrition; Nutritional Status; Observational studies; Older people; Prognosis; Prospective Studies; Treatment Outcome; Valerates - administration & dosage
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu16081223

Hip fractures are prevalent among older people, often leading to reduced mobility, muscle loss, and bone density decline. Malnutrition exacerbates the prognosis post surgery. This study aimed to evaluate the impact of a 12-week regimen of a high-calorie, high-protein oral supplement with β-hydroxy-β-methylbutyrate (HC-HP-HMB-ONS) on nutritional status, daily activities, and compliance in malnourished or at-risk older patients with hip fractures receiving standard care. A total of 270 subjects ≥75 years of age, residing at home or in nursing homes, malnourished or at risk of malnutrition, and post hip fracture surgery, received HC-HP-HMB-ONS for 12 weeks. Various scales and questionnaires assessed outcomes. During the 12 weeks of follow-up, 82.8% consumed ≥75% of HC-HP-HMB-ONS. By week 12, 62.4% gained or maintained weight (+0.3 kg), 29.2% achieved normal nutritional status (mean MNA score +2.8), and 46.8% improved nutritional status. Biochemical parameters improved significantly. Subjects reported good tolerability (mean score 8.5/10), with 87.1% of healthcare providers concurring. The administration of HC-HP-HMB-ONS markedly enhanced nutritional status and biochemical parameters in older hip-fracture patients, with high compliance and tolerability. Both patients and healthcare professionals expressed satisfaction with HC-HP-HMB-ONS.